Sonographic developmental milestones of the fetal cerebral cortex: a longitudinal study
Sonographic developmental milestones of the fetal cerebral cortex: a longitudinal study
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DOI：
10.1002/uog.2757
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发表时间：
2006-05-01
影响因子：
7.1
通讯作者：
Malinger, G.
中科院分区：
文献类型：
--
作者：
Cohen-Sacher, B.;Lerman-Sagie, T.;Malinger, G.
目的确定正常胎儿皮质发育的超声标志。方法从妊娠18周至足月每2周进行一次系列超声检查。在每次检查中，都会对胎儿大脑进行详细检查，并记录主要脑沟和脑回的外观。结果 22 名孕妇自愿参加该研究。胎儿皮质遵循有序的发育模式。到第 18 周时进行第一次超声检查时，出现了主要的裂隙。第一个脑沟最早可在 18 周时显现出来。以顶枕裂、扣带回和距状沟为代表的主要标志在 22-24 周之间出现。 28 周时，所有病例均出现中央沟。到30-32周时，大部分主脑沟均可显现。结论产前超声检查可准确显示胎儿皮质结构。将我们的结果与磁共振成像和其他超声检查研究的结果进行比较，显示脑沟和脑回的出现顺序相似，仅检测到它们的确切孕龄存在微小差异。准确了解妊娠不同阶段胎儿皮质的超声外观对于诊断子宫内皮质发育畸形非常重要。版权所有 (c) 2006 ISUOG。由约翰·威利父子有限公司出版
Objective To identify sonographic landmarks of normal fetal cortical development.Methods Serial ultrasound examinations were performed every 2 weeks from 18 weeks of gestation until term. In each session a detailed examination of the fetal brain was performed and the appearance of the main sulci and gyri was recorded.Results Twenty-two pregnant women volunteered to participate in the study. The fetal cortex followed an orderly pattern of development. By the time of the first ultrasound examination, at 18 weeks, the major fissures were present. The first sulci could be demonstrated as early as 18 weeks. Main landmarks, represented by the parieto-occipital fissure and the cingulate and calcarine sulci, were present between 22-24 weeks. The central sulcus was present in all cases by 28 weeks. By 30-32 weeks most of the main sulci could be demonstrated.Conclusions Prenatal sonograpbic examinations can accurately demonstrate structures of the fetal cortex. Comparison of our results with those of both magnetic resonance imaging and other sonograpbic studies shows similarities in the order of appearance of the sulci and gyri, with only minor differences in the exact gestational age at which they are detected. Accurate knowledge of the ultrasound appearance of the fetal cortex at different stages of gestation is important in order to be able to diagnose in-utero malformations of cortical development. Copyright (c) 2006 ISUOG. Published by John Wiley & Sons, Ltd.