Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory
Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory
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DOI：
10.1016/j.celrep.2020.108046
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发表时间：
2020-08-18
期刊：
影响因子：
8.8
通讯作者：
Soria-Gomez, Edgar
中科院分区：
文献类型：
--
作者：
da Cruz, Jose F. Oliveira;Busquets-Garcia, Arnau;Soria-Gomez, Edgar
一系列复杂的抑制性中间神经元紧密控制海马体的活动，但这种多样性如何具体影响记忆过程尚不清楚。我们发现，表达1型大麻素受体（CB1R）的海马体中间神经元的一个小亚类通过将多巴胺D - 1受体（D1R）信号传导与γ - 氨基丁酸能传递联系起来，决定了类情景记忆的巩固。在D - 1阳性细胞中缺乏CB1R的小鼠（D - 1 - CB1 - KO）在长期而非短期的新物体识别记忆（NOR）方面表现出损伤。在海马体D1R阳性细胞中重新表达CB1R可挽救这种NOR缺陷。学习诱导体内海马体长时程增强（LTP）的增强，而这种增强在突变小鼠中不存在。CB1R介导的NOR以及相关的LTP易化以依赖D - 1的方式涉及对γ - 氨基丁酸能抑制的局部控制。这项研究表明，表达海马体CB1R / D1R的中间神经元控制NOR记忆，确定了一种将海马体中间神经元的多样性与特定行为结果联系起来的机制。
A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid receptor (CB1R)-expressing hippocampal intemeurons determines episodic-like memory consolidation by linking dopamine D-1 receptor (D1R) signaling to GABAergic transmission. Mice lacking CB(1)Rs in D-1-positive cells (D-1-CB1-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB(1)Rs in hippocampal D1R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. CB1R-mediated NOR and the associated LTP facilitation involve local control of GABAergic inhibition in a D-1-dependent manner.This study reveals that hippocampal CB1R-/D1R-expressing interneurons control NOR memory, identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes.