Carboxylic Acid-Promoted Copper(I)-Catalyzed Azide-Alkyne Cycloaddition
Carboxylic Acid-Promoted Copper(I)-Catalyzed Azide-Alkyne Cycloaddition
复制标题
羧酸促进的铜(I)催化叠氮化物-炔烃环加成
DOI：
10.1021/jo101495k
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发表时间：
2010-10-15
影响因子：
3.6
通讯作者：
Hu, Yuefei
中科院分区：
文献类型：
--
作者：
Shao, Changwei;Wang, Xinyan;Hu, Yuefei
本文证明了CuAAC催化循环中的三个关键步骤都可以在羧酸存在下进行，且后两步能被羧酸显著地促进，其中苯甲酸的促进活性最好，而对Cu（I）离子螯合能力强的酸则不能达到这一目的。建立了第一个羧酸促进的高效CuAAC
In this article we proved that all three key steps in the catalytic cycle of CuAAC can proceed in the presence of carboxylic acids and the latter two steps can be promoted significantly by carboxylic acids Benzoic acid showed the best promotion activity and the acids with strong chelaung ability to Cu(I) ion could not serve or this purpose Thus. the first carboxylic acid-promoted highly efficient CuAAC was established