The distinguishing cellular features of pulmonary artery smooth muscle cells from chronic thromboembolic pulmonary hypertension patients
The distinguishing cellular features of pulmonary artery smooth muscle cells from chronic thromboembolic pulmonary hypertension patients
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慢性血栓栓塞性肺动脉高压患者肺动脉平滑肌细胞的独特细胞特征。
DOI：
10.3109/01902148.2013.822947
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发表时间：
2013-10-01
影响因子：
1.7
通讯作者：
Wang, Chen
中科院分区：
文献类型：
--
作者：
Wang, Lei;Gan, Hui-Li;Wang, Chen
在慢性血栓栓塞性肺动脉高压(CTEPH)中，中央血栓是最可能的致病因素，以肺动脉平滑肌细胞(PASMC)显著增殖为特征的进行性肺血管重构也可能导致CTEPH的长期进展。本研究旨在研究从CTEPH有组织的血栓组织中分离的PASMC的细胞特性。本研究对5例CTEPH患者和3例对照组的PASMC进行了分析，结果表明，CTEPH患者的PASMC具有不同于对照组的某些特征，包括弱细胞或无细胞接触抑制生长、对低氧诱导的增殖敏感性增加、对血清饥饿诱导的细胞凋亡的抵抗以及线粒体代谢障碍。CTEPH患者动脉内膜切除组织中PASMCs的这些差异可能有助于了解CTEPH的病理生物学。
In chronic thromboembolic pulmonary hypertension (CTEPH), central thrombi are the most likely disease initiators, and progressive pulmonary vascular remodeling, which is characterized by marked proliferation of pulmonary artery smooth muscle cells (PASMCs), may also contribute to the long-term progression of CTEPH. This study was designed to investigate the cellular characteristics of PASMCs isolated from the organized thrombotic tissues of CTEPH. In the present study, analysis of PASMCs isolated from five CTEPH patients and three control subjects showed that cells from CTEPH patients had certain characteristics that distinguished them from control cells, including inferior or no cell-cell contact inhibition growth, increased sensitivity to hypoxia-induced proliferation, resistance to serum starvation-induced apoptosis, and mitochondrial metabolism disorder. These differences in the PASMCs in endarterectomized tissue of CTEPH patients may prove useful in understanding the pathobiology of CTEPH.