Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris
Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris
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DOI：
10.1111/j.1365-2133.2008.08959.x
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发表时间：
2009-02-01
影响因子：
10.3
通讯作者：
Zouboulis, C. C.
中科院分区：
文献类型：
--
作者：
Ganceviciene, R.;Graziene, V.;Zouboulis, C. C.
皮脂腺具有独立的外周内分泌功能，并表达神经肽受体。以前的报道已经证实，在体外的人皮脂细胞中存在一个完整的促肾上腺皮质激素释放激素（CRH）系统。下丘脑CRH诱导脂质合成、诱导甾体生成并与睾酮和生长激素相互作用的能力暗示其参与痤疮临床发展的可能性。本研究的目的是检测CRH/CRH结合蛋白(CRHBP)/CRH受体（CRHRs）在痤疮累及皮肤，特别是皮脂腺中的表达变化。采用免疫组织化学方法分析了33例痤疮患者面部皮肤、同一患者未受损伤的大腿皮肤和8例年龄匹配的健康志愿者正常皮肤组织中CRH/CRHBP/CRHRs的表达。在痤疮受累皮肤的所有类型皮脂腺细胞中，无论其分化阶段如何，CRH的阳性反应都非常强烈，而在非受累皮肤和正常皮肤中，皮脂腺的CRH染色较弱，这取决于皮脂腺细胞的分化阶段。CRHBP在痤疮累及皮脂腺中最强烈的反应是分化皮脂细胞。CRHR-1和CRHR-2分别在汗腺和皮脂腺中表达最强。完整的CRH系统在痤疮相关皮肤中表达丰富，特别是在皮脂腺中，可能激活影响免疫和炎症过程的途径，导致痤疮的发展和应激性恶化。
The sebaceous gland exhibits an independent peripheral endocrine function and expresses receptors for neuropeptides. Previous reports have confirmed the presence of a complete corticotropin-releasing hormone (CRH) system in human sebocytes in vitro. The capability of hypothalamic CRH to induce lipid synthesis, induce steroidogenesis and interact with testosterone and growth hormone implicates a possibility of its involvement in the clinical development of acne.The purpose of the study was to detect expression changes of CRH/CRH binding protein (CRHBP)/CRH receptors (CRHRs) in acne-involved skin, especially in the sebaceous glands.Expression of CRH/CRHBP/CRHRs was analysed by immunohistochemistry in biopsies from facial skin of 33 patients with acne, noninvolved thigh skin of the same patients and normal skin of eight age-matched healthy volunteers.Very strong positive reaction for CRH was observed in acne-involved skin in all types of sebaceous gland cells, irrespective of their differentiation stage, whereas in noninvolved and normal skin sebaceous glands exhibited a weaker CRH staining depending upon the differentiation stage of sebocytes. The strongest reaction for CRHBP in acne-involved sebaceous glands was in differentiating sebocytes. CRHR-1 and CRHR-2 exhibited the strongest expression in sweat glands and sebaceous glands, respectively.Expression of the complete CRH system is abundant in acne-involved skin, especially in the sebaceous glands, possibly activating pathways which affect immune and inflammatory processes leading to the development and stress-induced exacerbation of acne.