Contact-Assisted Threading in Low-Homology Protein Modeling.
Contact-Assisted Threading in Low-Homology Protein Modeling.
复制标题
低同源性蛋白质建模中的接触辅助线程。
DOI：
10.1007/978-1-0716-2974-1_3
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Bhattacharya,Debswapna
中科院分区：
文献类型：
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作者：
Bhattacharya,Sutanu;Roche,Rahmatullah;Shuvo,MdHossain;Moussad,Bernard;Bhattacharya,Debswapna
从蛋白质的氨基酸序列成功地预测其三维结构的能力在最近的过去已经取得了相当大的进展。这一进展得益于基于深度学习的残基间接触图预测器的准确性提高，以及蛋白质序列数据库的不断增长。接触图编码原子间相互作用信息，其可以用于通过接触图线程高度准确地预测蛋白质结构，即使对于不适合直接同源建模的查询蛋白质也是如此。因此，接触辅助穿线已经获得了相当大的研究成果。在这一章中，我们提供了现有的接触辅助穿线方法的概述，同时强调了最近的进展，并讨论了一些目前的限制和未来的前景，在应用接触辅助穿线，以提高低同源蛋白质建模的准确性。
The ability to successfully predict the three-dimensional structure of a protein from its amino acid sequence has made considerable progress in the recent past. The progress is propelled by the improved accuracy of deep learning-based inter-residue contact map predictors coupled with the rising growth of protein sequence databases. Contact map encodes interatomic interaction information that can be exploited for highly accurate prediction of protein structures via contact map threading even for the query proteins that are not amenable to direct homology modeling. As such, contact-assisted threading has garnered considerable research effort. In this chapter, we provide an overview of existing contact-assisted threading methods while highlighting the recent advances and discussing some of the current limitations and future prospects in the application of contact-assisted threading for improving the accuracy of low-homology protein modeling.