Effect of mifepristone on the testosterone production of rat leydig cells in vitro
Effect of mifepristone on the testosterone production of rat leydig cells in vitro
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发表时间：
2002
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通讯作者：
Bai Shu-fan
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作者：
Bai Shu-fan
目的：探讨米非司酮对大鼠睾丸间质细胞基础及人绒毛膜促性腺激素（hCG）刺激的睾酮分泌的影响。方法：取成年Wistar大鼠睾丸间质细胞与米非司酮共同孵育，用放射免疫法测定孵育液中睾酮水平。结果：10μmol·L-1米非司酮组大鼠睾丸间质细胞基础及hCG刺激的睾酮分泌均受到抑制，抑制率分别为65 18%（P0 0 0 1）和72 78%（P0 0 5）。结论：米非司酮对大鼠睾丸间质细胞睾酮分泌有直接影响。
Objective:To investigate the effect of mifepristone on basal or Human chorionic gonadotropin(hCG)-stimulated testosterone production.Methods:Adult Wistar rats were sacrificed and Leydig cells were collected for incubation with drugs.Testoserone levels in incubates was measured by radioimmunoassay.Results:The basal and the hCG-stimulated testosterone production of rat Leydig cells in 10μmol·L -1 mifepristone group was inhibited,and the suppression rate was 65 18% ( P 0 001) and 72 78% ( P 0 05),respectively.Conclusion:These data suggested that mifepristone have a direct effect on testosterone production of Leydig cells.