Monosodium glutamate raises antral distension and plasma amino acid after a standard meal in humans
Monosodium glutamate raises antral distension and plasma amino acid after a standard meal in humans
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DOI：
10.1152/ajpgi.00299.2010
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发表时间：
2011-01-01
影响因子：
4.5
通讯作者：
Bos, Cecile
中科院分区：
文献类型：
--
作者：
Boutry, Claire;Matsumoto, Hideki;Bos, Cecile
人们提倡食用谷氨酸盐（MSG）以引起生理和代谢效应，但这些效应在人体中的直接研究很少，特别是在餐后阶段。13名健康成年人采用交叉设计，补充营养剂量的味精（2 g）或氯化钠（NaCl）作为对照，为期6天。在第7天，他们进行了一个完整的餐后检查6小时后，摄入相同的液体标准餐（700千卡，20%的能量为[N-15]蛋白质，50%的碳水化合物，30%的脂肪）补充味精或氯化钠。胃窦区的实际超声测量表明，与NaCl相比，补充味精的餐后2小时膨胀显著增加。这一餐后早期阶段也与MSG后循环亮氨酸、异亮氨酸、缬氨酸、赖氨酸、半胱氨酸、丙氨酸、酪氨酸和色氨酸水平显著升高相关。在补充味精和氯化钠的膳食之间，餐后血糖、胰岛素、胰高血糖素样肽（GLP）-1和胃饥饿素没有变化。主观评估的饥饿和饱胀既不受味精补充。最后，饮食N的餐后命运是相同的饮食条件。我们的研究结果表明，营养剂量的味精促进更大的餐后血浆中几种必需氨基酸的升高，并引起胃扩张。进一步的工作，以阐明可能的节约效应味精对人体不可缺少的氨基酸首过吸收是必要的。本试验在www.example.com上注册为NCT 00862017。
The consumption of monosodium glutamate (MSG) is advocated to elicit physiological and metabolic effects, yet these effects have been poorly investigated directly in humans and in particular in the postprandial phase. Thirteen healthy adults were supplemented for 6 days with a nutritional dose of MSG (2 g) or sodium chloride (NaCl) as control, following a crossover design. On the 7th day, they underwent a complete postprandial examination for the 6 h following the ingestion of the same liquid standard meal (700 kcal, 20% of energy as [N-15] protein, 50% as carbohydrate, and 30% as fat) supplemented with MSG or NaCl. Real-ultrasound measures of antral area indicated a significant increased distension for the 2 h following the meal supplemented with MSG vs. NaCl. This early postprandial phase was also associated with significantly increased levels of circulating leucine, isoleucine, valine, lysine, cysteine, alanine, tyrosine, and tryptophan after MSG compared with NaCl. No changes to the postprandial glucose, insulin, glucagon-like peptide (GLP)-1, and ghrelin were noted between MSG- and NaCl-supplemented meals. Subjective assessments of hunger and fullness were neither affected by MSG supplementation. Finally, the postprandial fate of dietary N was identical between dietary conditions. Our findings indicate that nutritional dose of MSG promoted greater postprandial elevations of several indispensable amino acids in plasma and induced gastric distension. Further work to elucidate the possible sparing effect of MSG on indispensable amino acid first-pass uptake in humans is warranted. This trial was registered at clinicaltrials.gov as NCT00862017.