Nanocarriers for nuclear imaging and radiotherapy of cancer
Nanocarriers for nuclear imaging and radiotherapy of cancer
复制标题
DOI：
10.2174/138161206779026317
复制
发表时间：
2006-01-01
影响因子：
3.1
通讯作者：
Ghandehari, Hamidreza
中科院分区：
文献类型：
--
作者：
Mitra, Amitava;Nan, Anjan;Ghandehari, Hamidreza
几种纳米尺度的载体(纳米颗粒、脂质体、水溶性聚合物、胶束和树枝状大分子)已经被开发出来，用于靶向输送癌症诊断和治疗药物。这些携带者可以选择性地瞄准癌症部位并携带大量有效载荷，从而提高癌症检测和治疗效果。此外，结合新的核成像技术提供高灵敏度和空间分辨率，如正电子发射断层扫描/计算机断层扫描(PET/CT)的双模式成像，以及使用纳米设备携带具有高靶点特异性的诊断和治疗核素，可以实现更准确的癌症检测、分期和治疗计划。放射性标记单抗在癌症检测和治疗中的成功临床应用预示着纳米级载体系统在临床肿瘤学中的良好前景。几种放射性标记的多功能纳米载体已经在动物模型中有效地检测和治疗癌症。尽管如此，还需要进一步的临床前、临床和长期毒性研究，以将这项技术转化为癌症患者的护理。本综述的目的是简要但全面地概述各种核成像技术以及利用纳米载体传递放射性核素用于癌症的诊断和治疗。
Several nanoscale carriers (nanoparticles, liposomes, water-soluble polymers, micelles and dendrimers) have been developed for targeted delivery of cancer diagnostic and therapeutic agents. These carriers can selectively target cancer sites and carry large payloads, thereby improving cancer detection and therapy effectiveness. Further, the combination of newer nuclear imaging techniques providing high sensitivity and spatial resolution such as dual modality imaging with positron emission tomography/computed tomography (PET/CT) and use of nanoscale devices to carry diagnostic and therapeutic radionuclides with high target specificity can enable more accurate detection, staging and therapy planning of cancer.The successful clinical applications of radiolabeled monoclonal antibodies for cancer detection and therapy bode well for the future of nanoscale carrier systems in clinical oncology. Several radiolabeled multifunctional nanocarriers have been effective in detecting and treating cancer in animal models. Nonetheless, further preclinical, clinical and long-term toxicity studies will be required to translate this technology to the care of patients with cancer. The objective of this review is to present a brief but comprehensive overview of the various nuclear imaging techniques and the use of nanocarriers to deliver radionuclides for the diagnosis and therapy of cancer.