EFFECTS OF AGE ON BEHAVIORAL SIGNS OF NEUROPATHIC PAIN IN AN EXPERIMENTAL RAT MODEL
EFFECTS OF AGE ON BEHAVIORAL SIGNS OF NEUROPATHIC PAIN IN AN EXPERIMENTAL RAT MODEL
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DOI：
10.1016/0304-3940(94)11113-w
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发表时间：
1995-01-02
影响因子：
2.5
通讯作者：
NA, HS
中科院分区：
文献类型：
--
作者：
CHUNG, JM;CHOI, Y;NA, HS
本研究探讨了衰老对神经病理性疼痛大鼠模型疼痛行为表现的影响。进行了两个实验。第一个实验比较了年轻，成熟和老年大鼠。在L5和L6节段脊神经的紧密结扎后，年轻大鼠比成熟或老年大鼠表现出更强烈的机械异常性疼痛和持续疼痛的行为体征。第二个实验使用相同的大鼠在两个不同的时间点进行。在大鼠幼年时在左侧进行脊神经结扎，20周后（成年年龄）在右侧重复相同的手术。左右侧疼痛行为的比较证实了第一个实验的结果。数据表明，与老年大鼠相比，年轻大鼠表现出更强烈的神经性疼痛行为体征。
The present study examined the effect that aging has on the manifestations of pain behaviors in a rat model of neuropathic pain. Two experiments were conducted. The first experiment compared young, mature and old rats. After tight ligation of the L5 and L6 segmental spinal nerves, young rats displayed much more vigorous behavioral signs of mechanical allodynia and ongoing pain than did either mature or old rats, The second experiment was done using the same rats at two different time points. Spinal nerve ligation was done on the left side of rats when they were young and the same surgery was repeated on the right side 20 weeks later (mature age). Comparison of pain behaviors between the left and right sides confirmed the results of the first experiment. The data suggest that younger rats show much more robust behavioral signs of neuropathic pain compared to older rats.