Effects of autologous adipose-derived stem cell infusion on type 2 diabetic rats
Effects of autologous adipose-derived stem cell infusion on type 2 diabetic rats
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DOI：
10.1507/endocrj.ej14-0584
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发表时间：
2015-04-20
影响因子：
2
通讯作者：
Yan, Shengli
中科院分区：
文献类型：
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作者：
Hu, Jianxia;Fu, Zhengju;Yan, Shengli
本研究旨在探讨脂肪干细胞（ASC）输注对2型糖尿病大鼠的治疗作用及其可能机制。将20只正常雄性SD大鼠作为正常对照组，40只雄性糖尿病大鼠随机分为糖尿病对照组和ASC组。观察治疗前后空腹血糖（FPG）、糖化血红蛋白（HbA1c）、血清胰岛素、C肽水平、胰岛细胞恢复情况、炎性细胞因子、胰岛素敏感性。与糖尿病对照组相比，ASC组输注ASC后2周内血糖明显改善，并维持6周左右，血浆胰岛素和C肽浓度明显改善（P
The effects and possible mechanisms of adipose-derived stem cells (ASC) infusion on type 2 diabetic rats were investigated in this study. Twenty normal male Sprague-Dawley rats were included in normal control group, and 40 male diabetic rats were randomly divided into diabetic control group and ASC group (which received ASC infusion). After therapy, levels of fasting plasma glucose (FPG), HbA1c, serum insulin and C-peptide, recovery of islet cells, inflammatory cytolcines, and insulin sensitivity were analyzed. After ASC infusion, compared with diabetic control group, hyperglycemia in ASC group was ameliorated in 2 weeks and maintained for about 6 weeks, and plasma concentrations of insulin and C-peptide were significantly improved (P