Nerve conduction block utilising high-frequency alternating current
Nerve conduction block utilising high-frequency alternating current
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DOI：
10.1007/bf02344716
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发表时间：
2004-05-01
影响因子：
3.2
通讯作者：
Bhadra, N
中科院分区：
文献类型：
--
作者：
Kilgore, KL;Bhadra, N
高频交流（AC）波形在动物模型中已被证明能产生快速可逆的神经阻滞，但这种阻滞的参数和机制尚不清楚。采用青蛙坐骨神经腓肠肌制备物，在体内检测神经传导阻滞的参数，并通过计算机模拟神经膜来确定神经传导阻滞的机制。结果表明，各种波形参数可以实现100%的运动活动阻滞，包括频率为2kHz至20kHz的正弦和矩形波形。34种神经制剂中有34种获得了完全可逆的阻滞。传导阻滞最有效的波形是3-5kHz恒流双相正弦波，刺激水平低至0.01 muCphase（-1）即可实现传导阻滞。结果表明，该砌块不是通过疲劳间接产生的。高频交流的计算机模拟显示了神经膜的稳态去极化，并且假设传导阻滞是由于这种强直性去极化。稳态去极化与传导阻滞之间的确切关系需要进一步分析。这项研究的结果表明，高频交流可以用来产生一种速效、快速可逆的神经传导阻滞，这种阻滞可能在治疗不必要的神经活动方面有多种应用。
High-frequency alternating current (AC) waveforms have been shown to produce a quickly reversible nerve block in animal models, but the parameters and mechanism of this block are not well understood. A frog sciatic nervel gastrocnemius muscle preparation was used to examine the parameters for nerve conduction block in vivo, and a computer simulation of the nerve membrane was used to identify the mechanism for block. The results indicated that a 100% block of motor activity can be accomplished with a variety of waveform parameters, including sinusoidal and rectangular waveforms at frequencies from 2kHz to 20kHz. A complete and reversible block was achieved in 34 out of 34 nerve preparations tested. The most efficient waveform for conduction block was a 3-5kHz constant-current biphasic sinusoid, where block could be achieved with stimulus levels as low as 0.01 muCphase(-1). It was demonstrated that the block was not produced indirectly through fatigue. Computer simulation of high-frequency AC demonstrated a steady-state depolarisation of the nerve membrane, and it is hypothesised that the conduction block was due to this tonic depolarisation. The precise relationship between the steady-state depolarisation and the conduction block requires further analysis. The results of this study demonstrated that high-frequency AC can be used to produce a fast-acting, and quickly reversible nerve conduction block that may have multiple applications in the treatment of unwanted neural activity.