Relationships between DNA repair and transcription.
Relationships between DNA repair and transcription.
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DOI：
10.1146/annurev.bi.65.070196.000311
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发表时间：
1996
影响因子：
16.6
通讯作者：
E. Friedberg
中科院分区：
文献类型：
--
作者：
E. Friedberg
在原核和真核细胞中，DNA修复和转录之间存在多种关系。首先，在原核生物和真核生物中，基因组转录活性区模板链的核苷酸切除修复速度比编码链快。在原核生物中，这种动力学差异的生化基础似乎与RNA聚合酶对修复和阻滞转录的特异性偶联有关。真核生物链特异性修复的生化基础尚不清楚。其次，在真核生物中，转录因子IIH （TFIIH）的部分或全部亚基是核苷酸切除修复所必需的。TFIIH蛋白这种双重功能的生物学意义尚不明显。最后，有迹象表明，与人类遗传性疾病科凯恩综合征有关的基因CSA和CSB可能在转录中起作用。
Multiple relationships have been noted between DNA repair and transcription in both prokaryotic and eukaryotic cells. First, in both prokaryotes and eukaryotes nucleotide excision repair of the template strand of transcriptionally active regions of the genome is faster than in the coding strand. In prokaryotes the biochemical basis for this kinetic difference appears to be related to the specific coupling of repair to arrested transcription by RNA polymerase. The biochemical basis for strand-specific repair in eukaryotes is unknown. Second, in eukaryotes some or all of the subunits of transcription factor IIH (TFIIH) are required for nucleotide excision repair. The biological significance of this dual function of TFIIH proteins is not obvious. Finally, there are indications that the genes CSA and CSB, which are implicated in the human hereditary disease Cockayne syndrome, may have a role in transcription.