Inputs of Macromolecular Engineering in the Design of Injectable Hydrogels Based on Synthetic Thermoresponsive Polymers
Inputs of Macromolecular Engineering in the Design of Injectable Hydrogels Based on Synthetic Thermoresponsive Polymers
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DOI：
10.1021/acs.macromol.9b00705
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发表时间：
2020-01-28
期刊：
影响因子：
5.5
通讯作者：
Gigmes, Didier
中科院分区：
文献类型：
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作者：
Pertici, Vincent;Trimaille, Thomas;Gigmes, Didier
在过去的几十年里，可注射水凝胶在药物输送和组织工程领域受到了高度关注，因为它们允许进行微创手术。其中，基于热响应性聚合物的水凝胶由于其制备条件简单、温和且可重复使用，仅依赖于加热时的自我重组而被认为是非常有兴趣的。可控/活性聚合技术和化学偶联技术的最新进展现在为实现精确工程和控制此类水凝胶性能提供了巨大的机会。从这个角度来看，我们的目标是强调它们在设计热响应结构方面的最新投入，以及它们如何解决凝胶行为、降解、生物功能化和受控药物输送的关键先决条件。
Injectable hydrogels have received high attention over the last decades in drug delivery and tissue engineering as they allow minimal invasive procedures. Among them, thermoresponsive-polymer-based hydrogels are considered of high interest owing to their simple, mild, and, reproducible preparation conditions, relying only on self-reorganization upon heating. Recent advances in controlled/ living polymerization techniques and chemical conjugation now offer tremendous opportunities for achieving precise engineering and control over such hydrogel properties. In this perspective, we aim at highlighting their recent inputs in the design of thermoresponsive architectures and how they can address key prerequisites of gelation behavior, degradation, biofunctionalization, and controlled drug delivery.