A case of hyperthymesia: rethinking the role of the amygdala in autobiographical memory.
A case of hyperthymesia: rethinking the role of the amygdala in autobiographical memory.
复制标题
心境亢进的一个案例：重新思考杏仁核在自传体记忆中的作用。
DOI：
10.1080/13554794.2011.654225
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发表时间：
2013
期刊：
影响因子：
0.8
通讯作者：
Donahue,ManusJ
中科院分区：
文献类型：
--
作者：
Ally,BrandonA;Hussey,ErinP;Donahue,ManusJ
杏仁核在自传体记忆核心网络中的地位一直备受争议。早期的证据表明，杏仁核在情绪处理中起着至关重要的作用，可能有助于编码充满情感的刺激。然而，最近的研究强调了杏仁核在社会和自我参照处理中的作用，导致人们猜测杏仁核可能支持AM的编码和提取。在这里，认知以及结构和功能磁共振成像数据收集从一个极其罕见的个人与近乎完美的AM，或hyperthymesia。相对于对照组，在该志愿者中观察到右侧杏仁核肥大（约20%）和杏仁核-海马连接增强（> 10 SD）。基于这些发现和以前的文献，我们推测杏仁核可能负责AM的情感，社会和自我相关性。在记忆增强的情况下，这个系统可能会过度活跃，允许许多类型的自传信息，包括情感上的良性信息，被更有效地处理为自我相关的编码和存储。
Much controversy has been focused on the extent to which the amygdala belongs to the autobiographical memory (AM) core network. Early evidence suggested the amygdala played a vital role in emotional processing, likely helping to encode emotionally charged stimuli. However, recent work has highlighted the amygdala's role in social and self-referential processing, leading to speculation that the amygdala likely supports the encoding and retrieval of AM. Here, cognitive as well as structural and functional magnetic resonance imaging data was collected from an extremely rare individual with near-perfect AM, or hyperthymesia. Right amygdala hypertrophy (approximately 20%) and enhanced amygdala-to-hippocampus connectivity (>10SDs) was observed in this volunteer relative to controls. Based on these findings and previous literature, we speculate that the amygdala likely charges AMs with emotional, social, and self-relevance. In heightened memory, this system may be hyperactive, allowing for many types of autobiographical information, including emotionally benign, to be more efficiently processed as self-relevant for encoding and storage.