PATHWAY FOR REMOVAL OF 15-ALPHA-METHYL GROUP OF LANOSTEROL - ROLE OF LANOST-8-ENE-3-BETA,32-DIOL IN CHOLESTEROL-BIOSYNTHESIS
PATHWAY FOR REMOVAL OF 15-ALPHA-METHYL GROUP OF LANOSTEROL - ROLE OF LANOST-8-ENE-3-BETA,32-DIOL IN CHOLESTEROL-BIOSYNTHESIS
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DOI：
10.1016/0045-2068(77)90046-3
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发表时间：
1977-01-01
影响因子：
5.1
通讯作者：
WILTON, DC
中科院分区：
文献类型：
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作者：
AKHTAR, M;FREEMAN, CW;WILTON, DC
合成[9.α.-3H]Lanost-7-ene-3.β-ol，并显示通过大鼠肝匀浆去甲基化，得到4,4''-二甲基cholesta-7,14-dien-3.β-ol。合成[32-3H]Lanost-8-ene-3.β.,32-二醇，并显示可通过大鼠肝微粒体制剂去甲基化，得到4,4''-二甲基cholesta-8,14-dien-3.β.-ol，并以甲酸形式释放C-32。
[9.alpha.-3H]Lanost-7-ene-3.beta.-ol is synthesized and is shown to be demethylated by a rat liver homogenate to give 4,4''-dimethylcholesta-7,14-dien-3.beta.-ol. [32-3H]Lanost-8-ene-3.beta.,32-diol is synthesized and shown to be demethylated by a rat liver microsomal preparation to give 4,4''-dimethylcholesta-8,14-dien-3.beta.-ol with release of C-32 as formic acid.