Balance between myogenic, flow-dependent, and metabolic flow control in coronary arterial tree: a model study
Balance between myogenic, flow-dependent, and metabolic flow control in coronary arterial tree: a model study
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DOI：
10.1152/ajpheart.00491.2001
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发表时间：
2002-06-01
影响因子：
4.8
通讯作者：
Spaan, JAE
中科院分区：
文献类型：
--
作者：
Cornelissen, AJM;Dankelman, J;Spaan, JAE
生肌反应、血流依赖性扩张和直接代谢控制是控制冠状动脉血流的重要机制。开发了一个模型来研究这些控制机制如何在小动脉树的不同位置相互作用，并评估它们对自动调节和代谢流量控制的贡献。该模型由10个串联的阻力隔室组成，每个隔室代表平行的血管单元，其直径由取决于流量和压力的张力[流量依赖性张力降低因子（TRFflow）x张力（myo）]或直接取决于代谢因子（张力（Meta））的张力确定。压力-张力（myo）和流量-TRFflow关系取决于从孤立血管数据插值获得的血管尺寸。与从仅受Tonemyo影响的血管获得的压力-流量线相比，流量依赖性扩张减少了自动调节特性。通过将Tonemeta应用于四个远端隔室，自动调节特性得以恢复，并且张力均匀地分布在隔室上。此外，代谢控制和阻断一氧化氮模拟。我们的结论是，需要一个平衡之间的流量依赖性的属性上游和收缩代谢性能下游。肌源性反应对血流调节有重要作用。
Myogenic response, flow-dependent dilation, and direct metabolic control are important mechanisms controlling coronary flow. A model was developed to study how these control mechanisms interact at different locations in the arteriolar tree and to evaluate their contribution to autoregulatory and metabolic flow control. The model consists of 10 resistance compartments in series, each representing parallel vessel units, with their diameters determined by tone depending on either flow and pressure [flow-dependent tone reduction factor (TRFflow) x Tone(myo)] or directly on metabolic factors (Tone(meta)). The pressure-Tone(myo) and flow-TRFflow relations depend on the vessel size obtained from interpolation of data on isolated vessels. Flow-dependent dilation diminishes autoregulatory properties compared with pressure-flow lines obtained from vessels solely influenced by Tonemyo. By applying Tonemeta to the four distal compartments, the autoregulatory properties are restored and tone is equally distributed over the compartments. Also, metabolic control and blockage of nitric oxide are simulated. We conclude that a balance is required between the flow-dependent properties upstream and the constrictive metabolic properties downstream. Myogenic response contributes significantly to flow regulation.