ACCELERATED HEALING OF INCISIONAL WOUNDS IN RATS INDUCED BY TRANSFORMING GROWTH-FACTOR-BETA
ACCELERATED HEALING OF INCISIONAL WOUNDS IN RATS INDUCED BY TRANSFORMING GROWTH-FACTOR-BETA
复制标题
DOI：
10.1126/science.2442813
复制
发表时间：
1987-09-11
期刊：
影响因子：
56.9
通讯作者：
DEUEL, TF
中科院分区：
文献类型：
--
作者：
MUSTOE, TA;PIERCE, GF;DEUEL, TF
通过分析转化生长因子-β的影响来研究多肽生长因子在炎症和修复过程中的作用。（TGF-β），直接应用于大鼠背部皮肤的线性切口。单一应用TGF-β的剂量依赖性直接刺激作用对愈合的切口伤口的断裂强度的影响。在第5天观察到最大伤口强度增加了对照的220%;在产生伤口并施用TGF-β后，愈合速率加速了约3天，持续至少14天。伤口强度的这些增加伴随着单核细胞和成纤维细胞流入的增加以及TGF-β施用部位的胶原沉积的显著增加。TGF-.beta.因此是可以加速大鼠伤口愈合的有效药理学试剂。
The role of polypeptide growth factors in the processes of inflammation and repair was investigated by analyzing the influence of transforming growth factor-.beta. (TGF-.beta.), applied directly to linear incisions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a single application of TGF-.beta. on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production of the wound and application of TGF-.beta.. These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-.beta.. TGF-.beta. is thus a potent pharmacologic agent that can accelerate wound healing in rats.