Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
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DOI：
10.1038/nn1471
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发表时间：
2005-06-01
影响因子：
25
通讯作者：
Grace, AA
中科院分区：
文献类型：
--
作者：
Goto, Y;Grace, AA
目标导向行为被认为涉及伏隔核 (NAcc) 中前额皮质和边缘输入的相互作用，并且中脑边缘多巴胺 (DA) 的调节似乎在 NAcc 功能中至关重要。通过同时对大鼠进行体内电生理记录和 DA 系统操作，我们发现强直性和阶段性 DA 释放分别通过 D1 和 D2 受体选择性调节海马和前额皮质输入。此外，我们还发现 NAcc 中的 D1 激活和 D2 失活产生了与特定传入相对应的行为选择性效应（反应策略的学习与设定转移）。这些结果表明，DA 释放的动力学通过伏隔核 DA 受体亚型的激活和失活来调节边缘和皮质驱动之间的平衡，从而调节目标导向的行为。
Goal-directed behavior is believed to involve interactions of prefrontal cortical and limbic inputs in the nucleus accumbens (NAcc), and their modulation by mesolimbic dopamine (DA) seems to be of primary importance in NAcc function. Using in vivo electrophysiological recordings simultaneously with DA system manipulation in rats, we show that tonic and phasic DA release selectively modulates hippocampal and prefrontal cortical inputs through D1 and D2 receptors, respectively. In addition, we also found that D1 activation and D2 inactivation in the NAcc produced behaviorally selective effects ( learning versus set shifting of response strategy) that correspond to specific afferents. These results suggest that the dynamics of DA release regulate the balance between limbic and cortical drive through activation and inactivation of DA receptor subtypes in the accumbens, and this regulates goal-directed behavior.