Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation
Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation
复制标题
DOI：
10.1016/j.clim.2017.08.015
复制
发表时间：
2018-02-01
影响因子：
8.6
通讯作者：
Mueller, Klaus
中科院分区：
文献类型：
--
作者：
Kielsen, Katrine;Shamim, Zaiba;Mueller, Klaus
白介素7是T细胞内稳态所必需的细胞因子。IL-7与细胞内的IL-7受体结合，与可溶性形式的受体(sIL-7Rα)竞争。我们推测，sIL-7Rα水平的改变可能会导致接受HSCT的患者的不良结局。同时，我们研究了与IL-7R释放相关的IL-7RαSNP rs6897932的影响。在造血干细胞移植期间，sIL-7Rα水平下降(从移植前的114 ng/ml下降到+14天的48 ng/ml(P<；0.0001)。这种模式与IL-7相反。发生II~IV级aGVHD患者+14d IL-7/sIL-7Rα比值显著高于对照组(OR=4.3P=0.026)。此外，供者携带rs6897932 T等位基因与sIL-7Rα水平降低、发生II-IV级aGVHD的风险增加(OR=2.4，P=0.055)和移植相关死亡率增加(CC=4.5%，CT=21.4%和TT=27.3%，P=0.0037)相关。(C)2017 Elsevier Inc.保留所有权利。
Interleukin-7 is a cytokine essential for T cell homeostasis. IL-7 binds to cellular IL-7 receptors in competition with a soluble form of the receptor (sIL-7R alpha). We hypothesized that altered sIL-7R alpha levels may cause adverse outcomes in patients undergoing HSCT. In parallel, we investigated the impact of the IL-7R alpha SNP rs6897932, which has been associated with release of IL-7R.The sIL-7R alpha levels decreased during HSCT (from 114 ng/ml before to 48 ng/ml at day + 14 (P < 0.0001)). This pattern was inversely mirrored by IL-7. The IL-7/sIL-7R alpha ratio at day + 14 was significantly higher in patients developing grades II-IV aGVHD (OR = 4.3, P = 0.026). Furthermore, donor carriage of the rs6897932 T allele was associated with reduced sIL-7R alpha levels, increased risk of grades II-IV aGVHD (OR = 2.4, P = 0.055) and increased transplant-related mortality (CC = 4.5%, CT = 21.4% and TT = 27.3%, P = 0.0037).In conclusion, this study suggests an impact of sIL-7R alpha levels and rs6897932 donor genotype on alloreactivity and outcome after HSCT. (C) 2017 Elsevier Inc. All rights reserved.