Comparison of responses to novel nitric oxide donors in the feline pulmonary vascular bed
Comparison of responses to novel nitric oxide donors in the feline pulmonary vascular bed
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DOI：
10.1016/s0014-2999(01)01289-4
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发表时间：
2001-11-02
影响因子：
5
通讯作者：
Kadowitz, PJ
中科院分区：
文献类型：
--
作者：
De Witt, BJ;Marrone, JR;Kadowitz, PJ
本文观察并比较了一氧化氮（NO）供体二乙胺/NO、二乙烯三胺/NO、精胺/NO、亚硫酸盐/NO和安氏盐（angeli 'ssalt）对猫肺血管的反应。在控制血流的条件下，当肺血管床张力升高到较高的稳定水平时，叶内注射二乙胺/NO（0.3-10 μ g）、二亚乙基三胺/NO（10-30 μ g）、精胺/NO（10 - 30 μ g）、亚硫酸盐/NO（10-30 μ g）和安杰利盐（10-30 μ g）引起剂量相关的叶动脉压降低，而不改变左心房压。就肺血管床中的相对血管舒张活性而言，与S-亚硝基-N-乙酰青霉胺相比，二乙胺/NO降低叶动脉压4 mm Hg（ED 4 mm Hg）的化合物的剂量显著较低，S-亚硝基-N-乙酰青霉胺显著低于二亚乙基三胺/NO、精胺/NO、亚硫酸盐/NO和安氏盐。对于具有相似血管舒张幅度的剂量，血管舒张剂对二乙胺/NO、二亚乙基三胺/NO、精胺/NO、亚硫酸盐/NO和安杰利盐的反应的半衰期（通过50%反应恢复时间测量）相似，而对S-亚硝基-N-乙酰青霉胺的半衰期显著小于二醇二氮烯鎓 NO供体。目前的数据表明，diazeniumdiolate NO供体二乙胺/NO、二亚乙基三胺/NO、精胺/NO、亚硫酸盐/NO和angeli盐在猫的肺血管床中具有有效但相对短暂的血管扩张活性。
Pulmonary vascular responses to the novel diazeniumdiolate nitric oxide (NO) donors diethylamine/NO, diethylenetriamine/NO, spermine/NO, sulfite/NO, and angeli's salt, were investigated and compared in the intact-chest cat. Under conditions of controlled blood flow, when tone in the pulmonary vascular bed had been raised to a high steady level, intralobar injections of diethylamine/NO (0.3-10 mug), diethylenetriamine/NO (10-30 mug), spermine/NO (10-30 mug), sulfite/NO (10-30 mug), and angeli's salt (10-30 mug) caused dose-related decreases in lobar arterial pressure without changing left atrial pressure. In terms of relative vasodilator activity in the pulmonary vascular bed, the dose of the compounds that decreased lobar arterial pressure 4 mm Hg (ED4 mm Hg) was significantly lower for diethylamine/NO compared to S-nitroso-N-acetylpenicillamine which was significantly less than diethylenetriamine/NO, spermine/NO, sulfite/NO, and angeli's salt. The half-life of the vasodilator responses, as measured by 50% response recovery time, to diethylamine/NO, diethylenetriamine/NO, spermine/NO, sulfite/NO, and angeli's salt was similar for doses with similar magnitudes of vasodilation, while the half-life to S-nitroso-N-acetylpenicillamine was significantly less than the diazeniumdiolate NO donors. The present data demonstrate that the diazeniumdiolate NO donors diethylamine/NO, diethylenetriamine/NO, spermine/NO, sulfite/NO, and angeli's salt have potent but relatively short-lasting vasodilator activity in the pulmonary vascular bed of the cat. (C) 2001 Published by Elsevier Science B.V.