The Contributions of Prefrontal Cortex and Executive Control to Deception: Evidence from Activation Likelihood Estimate Meta-analyses
The Contributions of Prefrontal Cortex and Executive Control to Deception: Evidence from Activation Likelihood Estimate Meta-analyses
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DOI：
10.1093/cercor/bhn189
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发表时间：
2009-07-01
期刊：
影响因子：
3.7
通讯作者：
McDermott, Kathleen B.
中科院分区：
文献类型：
--
作者：
Christ, Shawn E.;Van Essen, David C.;McDermott, Kathleen B.
先前的神经影像学研究表明，前额叶皮层（PFC）和附近的大脑区域与欺骗有关。这与说谎涉及执行控制系统的假设是一致的。然而，迄今为止，行政控制的不同方面对欺骗的贡献的性质仍不清楚。在本研究中，我们利用元分析的激活可能性估计（ALE）方法来定量识别在过去的研究中相对于真实反应，欺骗性反应始终更活跃的大脑区域。然后，我们将结果与执行控制的3个不同方面（工作记忆、抑制控制和任务切换）生成的附加ALE图进行了对比。背外侧PFC和后顶叶皮层中的欺骗相关区域选择性地与工作记忆相关。腹外侧PFC、前扣带回和前扣带皮层中的其他欺骗区域与执行控制的多个方面相关。相反，双侧顶下小叶的欺骗相关区域与3个执行控制结构中的任何一个都不相关。我们的研究结果支持的概念，即执行控制过程，特别是工作记忆，以及它们相关的神经基质在欺骗中发挥不可或缺的作用。这项工作提供了一个基础，为未来的研究欺骗的神经认知基础。
Previous neuroimaging studies have implicated the prefrontal cortex (PFC) and nearby brain regions in deception. This is consistent with the hypothesis that lying involves the executive control system. To date, the nature of the contribution of different aspects of executive control to deception, however, remains unclear. In the present study, we utilized an activation likelihood estimate (ALE) method of meta-analysis to quantitatively identify brain regions that are consistently more active for deceptive responses relative to truthful responses across past studies. We then contrasted the results with additional ALE maps generated for 3 different aspects of executive control: working memory, inhibitory control, and task switching. Deception-related regions in dorsolateral PFC and posterior parietal cortex were selectively associated with working memory. Additional deception regions in ventrolateral PFC, anterior insula, and anterior cingulate cortex were associated with multiple aspects of executive control. In contrast, deception-related regions in bilateral inferior parietal lobule were not associated with any of the 3 executive control constructs. Our findings support the notion that executive control processes, particularly working memory, and their associated neural substrates play an integral role in deception. This work provides a foundation for future research on the neurocognitive basis of deception.