RPL36 as a prognostic marker in hepatocellular carcinoma
RPL36 as a prognostic marker in hepatocellular carcinoma
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DOI：
10.1111/j.1440-1827.2011.02716.x
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发表时间：
2011-11-01
影响因子：
2.2
通讯作者：
Yoon, Seung Kew
中科院分区：
文献类型：
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作者：
Song, Myeong Jun;Jung, Chan Kwon;Yoon, Seung Kew
核糖体蛋白（RP）在细胞凋亡、多药耐药和肿瘤发生中起着重要的调节作用。本研究旨在探讨核糖体蛋白L36（RPL 36）在肝细胞癌（HCC）中的表达及其与临床病理参数和临床预后的关系。肝脏标本来自60例接受部分肝切除术的HCC患者。通过免疫组织化学在组织微阵列上评估RPL 36在肿瘤组织和周围非肿瘤组织中的表达。RPL 36在60例HCC中有45例（75%）表达，但在相应的非肿瘤组织中未检测到。RPL 36表达与反映肝脏合成功能的血清白蛋白（P = 0.044）和凝血酶原时间（P = 0.026）水平显著相关。此外，RPL 36的表达在具有早期肿瘤阶段（I/II）（P = 0.038）或没有门静脉血栓形成（P = 0.005）的患者中被发现更高。在单因素分析中，RPL 36表达的患者显示更好的总生存期（P = 0.037）。多因素生存分析显示，RPL 36表达是影响总生存率的独立预后因素（P = 0.026）。我们的数据表明，RPL 36可能参与了肝癌的早期阶段，它可以作为一个独立的和潜在的预后指标切除肝癌。
Ribosomal proteins (RP) play key roles in the regulation of apoptosis, multidrug resistance and carcinogenesis. The aim of this study was to investigate the expression of ribosomal protein L36 (RPL36) in hepatocellular carcinoma (HCC) and to correlate it with clinicopathological parameters and clinical outcome. Liver specimens were obtained from 60 HCC patients who had undergone a partial hepatectomy. Expression of RPL36 in tumor tissue and surrounding non-tumorous tissues was evaluated on a tissue microarray by immunohistochemistry. RPL36 was expressed in 45 of 60 (75%) HCC by immunohistochemistry, but was not detected in corresponding non-tumors. RPL36 expression correlated significantly with serum levels of albumin (P = 0.044) and prothrombin time (P = 0.026), which reflect liver synthetic function. Moreover, expression of RPL36 was found to be higher in patients with early tumor stages (I/II) (P = 0.038) or without portal vein thrombosis (P = 0.005). In univariate analysis, patients with RPL36 expression revealed better overall survival (P = 0.037). By multivariate survival analysis, RPL36 expression was found to be an independent prognostic factor for overall survival (P = 0.026). Our data suggest that RPL36 may be involved in the early stage of hepatocarcinogenesis, and it can be used as an independent and potential prognostic marker for resected HCC.