A DEVELOPMENTAL-STUDY OF SEX AND AGE INTERACTIONS IN THE HUMAN CORPUS-CALLOSUM
A DEVELOPMENTAL-STUDY OF SEX AND AGE INTERACTIONS IN THE HUMAN CORPUS-CALLOSUM
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DOI：
10.1016/0165-3806(92)90079-c
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发表时间：
1992-04-24
期刊：
影响因子：
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通讯作者：
DENENBERG, VH
中科院分区：
文献类型：
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作者：
COWELL, PE;ALLEN, LS;DENENBERG, VH
胼胝体（CC）的区域分析表明，该纤维束的发育是两性二态的。采用计算机辅助软件对73对年龄匹配（2-79岁）的男性和女性的核磁共振图像（mri）中矢状面CC示踪进行数字化。获得面积、轴长、周长和99宽度。根据先前因子分析，将宽度分为以下区域：宽度3-18 （W3-18）、W22-39、W49-62、W65-74、W77-85、W89-94和W95-99。以性别和年龄（以10年为单位）作为独立变量进行趋势分析。高阶性别年龄交互作用在W3-18和W22-39区显著，在W95-99区边缘。在所有3个地区。女性直到41-50岁才达到最大宽度，而男性在20岁时达到峰值，此后下降。在其余CC区域中，性别和年龄之间没有显著的相互作用，在成年期达到最大宽度后，也没有任何显著的减少。这些结果表明，在人类的一生中，CC的超微结构也可能存在性别差异。
Regional analysis of the corpus callosum (CC) has demonstrated that the development of this fiber tract is sexually dimorphic. Midsagittal CC tracings from magnetic resonance images (MRIs) of 73 pairs of age-matched (age 2-79 years) males and females were digitized using computer assisted software. Area, axis length, perimeter, and 99 widths were obtained. Widths were grouped into the following regions based upon prior factor analysis: widths 3-18 (W3-18), W22-39, W49-62, W65-74, W77-85, W89-94, and W95-99. Trend analyses were performed with Sex and Age (blocked into 10-year bins) as independent variables. Higher order Sex by Age interactions were significant in regions W3-18 and W22-39 and were marginal in W95-99. In all 3 regions. females did not attain maximum width until Age 41-50 whereas males had peaked at 20 years and declined thereafter. There were no significant interactions between Sex and Age in the remaining CC regions, nor were there any dramatic decreases once maximum width was reached in adulthood. These results suggest that sex differences may also exist in CC ultrastructure over the human lifespan.