Bidirectional connectivity between hemispheres occurs at multiple levels in language processing but depends on sex.
Bidirectional connectivity between hemispheres occurs at multiple levels in language processing but depends on sex.
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DOI：
10.1523/jneurosci.1245-10.2010
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发表时间：
2010-09-01
期刊：
影响因子：
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通讯作者：
Booth JR
中科院分区：
文献类型：
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作者：
Bitan T;Lifshitz A;Breznitz Z;Booth JR
我们的目的是确定语音任务中涉及不同处理级别的区域中半球间交流的方向。对 39 名儿童（9-15 岁）对口头单词进行押韵判断的功能磁共振成像数据进行了有效的连接分析。结果显示半球之间在多个层面上的相互作用：在初级听觉皮层的感觉层面上存在从右到左的单向信息传递。其次，颞上回之间的双向连接表明半球之间在语音和韵律处理水平上的相互合作。第三，从右侧 STG 到左侧额下回的直接连接表明，在右侧 STG 中处理的信息被整合到押韵决策所需的音系分割的最后阶段。与右半球相比，左半球从初级听觉皮层到 STG 的半球内连接更强。这些结果支持半球之间的合作模型，具有不对称的半球间和半球内连接性，与左半球语音处理的专门化一致。最后，我们发现，与男孩相比，女孩的半球间连接性更强，这与女性比男性更具有双边语言表征的假设相一致。然而，大脑半球间的交流与女孩的表现迟缓和语言智商低有关。我们认为，女性可能具有更大的半球间合作潜力，这可能在某些任务中具有优势。然而，在其他任务中，半球之间过多的交流可能会干扰任务表现。
Our aim was to determine the direction of inter-hemispheric communication in a phonological task, in regions involved in different levels of processing. Effective connectivity analysis was conducted on fMRI data from 39 children (9–15) performing rhyming judgment on spoken words. The results show interaction between hemispheres at multiple levels: There is unidirectional transfer of information from right to left at the sensory level of primary auditory cortex. Second, bidirectional connections between superior temporal gyri, suggest a reciprocal cooperation between hemispheres at the level of phonological and prosodic processing. Third, a direct connection from right STG to left inferior frontal gyrus suggest that information processed in the right STG is integrated into final stages of phonological segmentation required for the rhyming decision. Intra-hemispheric connectivity from primary auditory cortex to STG was stronger in the left compared to the right hemisphere. These results support a model of cooperation between hemispheres, with asymmetric inter and intra- hemispheric connectivity consistent with the left hemisphere specialization for phonological processing. Finally, we found greater inter-hemispheric connectivity in girls compared to boys, consistent with the hypothesis of a more bilateral representation of language in females than males. However, inter-hemispheric communication was associated with slow performance and low verbal IQ within girls. We suggest that females may have the potential for greater inter-hemispheric cooperation, which may be an advantage in certain tasks. However in other tasks, too much communication between hemispheres may interfere with task performance.