Sangelose-based gels and films: effects of glycerol and α-cyclodextrin and their pharmaceutical application
Sangelose-based gels and films: effects of glycerol and α-cyclodextrin and their pharmaceutical application
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桑吉露基凝胶和薄膜：甘油和α-环糊精的作用及其药物应用
DOI：
10.1080/03639045.2023.2182127
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发表时间：
2023
影响因子：
3.4
通讯作者：
Kondo Hiromu
中科院分区：
文献类型：
--
作者：
Terukina Takayuki;Tanaka Jun;Takayama Yumi;Osanai Kaede;Kino Shusuke;Kanazawa Takanori;Kondo Hiromu
目的探讨桑戈糖作为明胶和卡拉胶替代品在薄膜基质开发中的应用，研究了甘油和α-环糊精（α-CyD）对三白葡萄糖凝胶的粘弹性和膜的物理性能的影响，结果表明，三白葡萄糖凝胶/膜可作为明胶和角叉菜胶的潜在替代品将增塑剂α-CyD和功能性添加剂α-CyD分别加入到Sangelose中，制备凝胶和成膜。动态粘弹性测量的凝胶进行了评价，并通过扫描电子显微镜，傅里叶变换红外光谱，拉伸试验，接触角测量和膜进行了评价。结果单加甘油对凝胶强度有一定影响，而α-CyD的加入使凝胶强度变硬。然而，添加α-CyD与10%甘油削弱了凝胶。拉伸试验表明，甘油的加入影响了薄膜的成型性和延展性，而α-CyD的加入影响了薄膜的成型性和延伸性。添加10%甘油和α-CyD不会影响膜的柔韧性，表明延展性和强度受到影响。单加甘油或α-CyD不能制备软胶囊。结论适量的甘油和α-CyD与山当归糖复合后具有良好的成膜特性，在医药和保健食品领域具有潜在的应用价值。
ObjectiveTo evaluate the possible application of Sangelose as an alternative to gelatin and carrageenan for the development of film substrates, and to examine the effect of glycerol and α-cyclodextrin (α-CyD) on the viscoelastic properties of Sangelose-based gels and the physical properties of the films.SignificanceSangelose-based gels/films can serve as a potential viable alternative to gelatin and carrageenan in pharmaceutical applications.MethodsGlycerol (a plasticizer) and α-CyD (a functional additive) were added to Sangelose, and gels and films were prepared. The gels were evaluated by dynamic viscoelasticity measurements, and the films were evaluated by scanning electron microscopy, Fourier-transform infrared spectroscopy, tensile tests, and contact angle measurements. Soft capsules were prepared using the formulated gels.ResultsThe strength of the gels was affected when only glycerol was added to Sangelose and α-CyD addition resulted in rigid gels. However, the addition of α-CyD with 10% glycerol weakened the gels. Tensile tests suggested that glycerol addition affected the formability and malleability of the films, while α-CyD addition affected their formability and elongation properties. The addition of 10% glycerol and α-CyD did not affect the flexibility of the films, suggesting that the malleability and strength were impacted. Soft capsules could not be prepared by adding only glycerol or α-CyD to Sangelose. Soft capsules with favorable disintegration behavior were obtained upon adding α-CyD to gels along with 10% glycerol.ConclusionsSangelose combined with a suitable amount of glycerol and α-CyD has preferable characteristics for film formation and may have potential applications in the pharmaceutical and health food sectors.
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