Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions
Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions
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DOI：
10.4049/jimmunol.180.3.1362
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发表时间：
2008-02-01
影响因子：
4.4
通讯作者：
Marincola, Francesco M.
中科院分区：
文献类型：
--
作者：
Deola, Sara;Panelli, Monica C.;Marincola, Francesco M.
表达cd8的细胞毒性T细胞（CTL）与apc和辅助T细胞的相互作用决定了它们的功能和生存能力。在这项研究中，我们描述了激活的ctl和表达cd19的B淋巴细胞之间独立于Ag呈递的一种新的相互作用。ag刺激的ctl通过CD27/CD70与自体B淋巴细胞接触，促进其存活和增殖。此外，这些相互作用诱导促炎细胞因子的释放遵循两种一般模式：1)依赖于表位的细胞因子释放增强，以及2)先前未发现的独立于表位暴露的细胞因子的协调释放。后者包括靶向活化T细胞的化学引诱剂。结果，被激活的T细胞被B细胞吸引，B细胞在淋巴器官或炎症区域发挥“辅助”作用。这一观察结果为先前报道的实验观察结果提供了一种机制解释，表明B细胞是体内T细胞启动所必需的。
CD8-expressing cytotoxic T cell (CTL) interactions with APCs and helper T cells determine their function and ability to survive. In this study, we describe a novel interaction independent of Ag presentation between activated CTLs and bystander CD19-expressing B lymphocytes. Ag-stimulated CTLs serially engage autologous B lymphocytes through CD27/CD70 contact that promotes their survival and proliferation. Moreover, these interactions induce the release of proinflammatory cytokines that follows two general patterns: 1) an epitope-dependent enhancement of cytokine release, and 2) a previously undiscovered coordinate release of cytokines independent of epitope exposure. The latter includes chemoattractants targeting activated T cells. As a result, activated T cells are attracted to B cells, which exert a "helper" role in lymphatic organs or in areas of inflammation. This observation provides a mechanistic explanation to previously reported experimental observations suggesting that B cells are required for T cell priming in vivo.