Inter-rater agreement of assessed prenatal maternal occupational exposures to lead
Inter-rater agreement of assessed prenatal maternal occupational exposures to lead
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DOI：
10.1002/bdra.20311
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发表时间：
2006-11-01
影响因子：
--
通讯作者：
Jackson, Leila W.
中科院分区：
文献类型：
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作者：
Correa, Adolfo;Min, Yuan-I;Jackson, Leila W.
背景技术背景：基于父母工作史的产前职业暴露的工业卫生学家的评估是一种有前途的方法，以人口为基础的出生缺陷和其他围产期结局的病例对照研究。然而，评价者之间的协议，这样的assessment.METHODS：我们研究了评价者之间的协议，职业性铅暴露评估的母亲工作报告的工业卫生学家在一个以人口为基础的病例对照研究，父母职业性铅暴露和低出生体重。在怀孕前6个月至怀孕结束期间，共检查了178个可能接触铅的工作。三名工业卫生学家独立评估了这些工作的铅暴露情况，包括暴露概率、暴露类型、进入途径、暴露频率、持续时间和强度。评价者间的协议，这些评估超越机会进行了评价，使用kappa统计（kappa）。结果：在一般情况下，评价者间的协议是更大的直接暴露评估比间接暴露评估。然而，评估者间的一致性随所考虑的铅暴露指标而变化，包括：1）直接暴露类型的一般至良好（即，无机或有机）、呼吸道暴露和直接无机铅暴露频率、每天直接（即，无机或有机），以及直接无机暴露强度; 2）间接暴露的概率和类型差（无机或有机）; 3）直接有机暴露频率、间接暴露频率不确定（有机或无机）和直接暴露强度（有机或无机）。回顾性评估母亲产前暴露于铅的工业卫生学家可以提供一些可靠的指标暴露的研究围产期的结果。这种暴露评估的可靠性研究可能是有用的：量化衍生的暴露度量的可靠性;确定暴露度量的风险结果分析;和确定产前职业暴露的其他代理人的利益的可靠性。出生缺陷研究（A部分）76：811-824，2006年。(C)2006 Wiley-Liss，Inc.（匕首）
BACKGROUND: Industrial hygienists' assessments of prenatal occupational exposures based on parental job histories is a promising approach for population-based case-control studies of birth defects and other perinatal outcomes. However, evaluations of inter-rater agreement of such assessments have been limited.METHODS: We examined inter-rater agreement of occupational lead exposure assessments of maternal job reports by industrial hygienists in a population-based case-control study of parental occupational lead exposure and low birth weight. A total of 178 jobs with potential exposure to lead during the 6 months before pregnancy to the end of pregnancy were examined. Three industrial hygienists evaluated these jobs independently for exposure to lead including probability of exposure, type of exposure, route of entry, exposure frequency, duration, and intensity. Inter-rater agreement of these assessments beyond chance was evaluated using the kappa statistic (kappa).RESULTS: In general, inter-rater agreement was greater for assessment of direct exposures than assessment of indirect exposures. However, inter-rater agreement varied with the lead exposure metric under consideration, being: 1) fair to good for type of direct exposure (i.e., inorganic or organic), respiratory exposure and frequency of exposure to direct inorganic lead, hours per day of direct (i.e., inorganic or organic), and intensity of direct inorganic exposure; 2) poor for probability and type of indirect exposure (inorganic or organic); and 3) indeterminate for frequency of direct organic exposure, frequency of indirect exposures (organic or inorganic), and intensity of direct exposures (organic or inorganic).CONCLUSION: Retrospective assessment of maternal prenatal exposures to lead by industrial hygienists can provide some reliable metrics of exposure for studies of perinatal outcomes. Reliability studies of such exposure assessments may be useful for: quantifying the reliability of derived exposure metrics; identifying exposure metrics for exposure-outcome analyses; and determining the reliability of prenatal occupational exposures to other agents of interest. Birth Defects Research (Part A) 76:811-824, 2006. (C) 2006 Wiley-Liss, Inc.(dagger)