Age-independent and dose-response effects of ethanol on spatial memory in rats
Age-independent and dose-response effects of ethanol on spatial memory in rats
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DOI：
10.1016/s0741-8329(01)00127-6
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发表时间：
2001-04-01
期刊：
影响因子：
2.3
通讯作者：
Swartzwelder, HS
中科院分区：
文献类型：
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作者：
Acheson, SK;Ross, EL;Swartzwelder, HS
以前的研究结果表明，乙醇在低于损害成年大鼠空间记忆获得所需的剂量时，会损害青春期大鼠的空间记忆获得。然而，之前的工作没有确定乙醇的剂量不会损害青少年的获得性，或者损害青少年和成年动物的获得性。这是我们在本研究中的目的。雄性长帽大鼠(青春期和成年组)在每天进行空间版或非空间版Morris水迷宫训练前30分钟分别给予0.0g/kg、0.5g/kg或2.5g/kg的乙醇。在进行空间任务训练24小时后，对这些动物进行了1分钟的探测试验。低剂量的乙醇(0.5g/kg)不会损害任何年龄段的动物在任何任务中的表现。然而，它确实提高了空间任务的初始习得速度。2.5g/kg剂量消除了两个年龄段的动物的空间学习获得，并显著削弱了两个年龄段的非空间任务的表现。然而，通过控制基线成绩，非空间任务中的处理效应被消除。这些结果确定了低剂量的乙醇(0.5g/kg)不会损害青春期或成年大鼠的空间记忆获得。此外，研究结果表明，2.5g/kg的乙醇显著损害了青少年和成年动物的空间记忆获得。(C)2001 Elsevier Science Inc.保留所有权利。
Results of previous studies have shown that ethanol impairs the acquisition of spatial memory in adolescent rats at doses below those required to impair the acquisition in adults. However, the previous work did not identify doses of ethanol that failed to impair acquisition in adolescents or that impaired acquisition in both adolescent and adult animals. This was our aim in the present study. Male, Long-Evans hooded rats (adolescent and adult) were treated intraperitoneally with 0.0, 0.5, or 2.5 g/kg of ethanol 30 min before daily training on a spatial or nonspatial version of the Morris water maze task. Twenty-four hours after training on the spatial task the animals were given a 1-min probe trial. The low dose of ethanol (0.5 g/kg) failed to impair the performance of animals from either age group on any tasks. It did, however, enhance the initial rate of acquisition on the spatial task. The 2.5-g/kg dose eliminated acquisition of spatial learning in animals of both ages and significantly attenuated performance on a nonspatial task in both age groups. However, the treatment effect in the nonspatial task was eliminated with controlling for baseline performance. These results establish a low dose of ethanol (0.5 g/kg) that does not impair acquisition of spatial memory in adolescent or adult rats. Moreover, the study findings show that 2.5 g/kg of ethanol markedly impairs acquisition of spatial memory in both adolescent and adult animals. (C) 2001 Elsevier Science Inc. All rights reserved.