Signal-to-noise performance evaluation of a new 12-bit digitizer on a time-of-flight mass spectrometer
Signal-to-noise performance evaluation of a new 12-bit digitizer on a time-of-flight mass spectrometer
复制标题
DOI：
10.1255/ejms.1316
复制
发表时间：
2015-01-01
影响因子：
1.3
通讯作者：
Toyoda, Michisato
中科院分区：
文献类型：
--
作者：
Hondo, Toshinobu;Kawai, Yousuke;Toyoda, Michisato
使用新推出的12位数字化仪Keysight U 5303 A型，研究了从平均较少的采集中快速采集飞行时间（TOF）光谱。在相同的信噪比（S/N）下，这有望实现比常用的8位数字化仪快32倍的频谱采集。平均较少的脉冲提高了检测速度和色谱分离性能。然而，增加高频信号（例如TOF频谱）的模数转换器位分辨率会增加系统噪声，并且需要使定时抖动（孔径误差）最小化。我们研究了S/N比与使用U 5303 A的平均采集次数之间的关系，并将其与8位数字化仪进行了比较。结果表明，噪声，测量为均方根，线性下降到没有背景扣除的平均采集次数的平方根，这意味着几乎没有系统噪声存在于我们的信号带宽的兴趣（几百兆赫）。相比之下，市场上常用的8位数字化仪需要32倍以上的脉冲，并进行背景减除。
Rapid acquisition of time-of-flight (TOF) spectra from fewer acquisitions on average was investigated using the newly introduced 12-bit digitizer, Keysight model U5303A. This is expected to achieve a spectrum acquisition 32 times faster than the commonly used 8-bit digitizer for an equal signal-to-noise (S/N) ratio. Averaging fewer pulses improves the detection speed and chromatographic separation performance. However, increasing the analog-to-digital converter bit resolution for a high-frequency signal, such as a TOF spectrum, increases the system noise and requires the timing jitter (aperture error) to be minimized. We studied the relationship between the S/N ratio and the average number of acquisitions using U5303A and compared this with an 8-bit digitizer. The results show that the noise, measured as root-mean-square, decreases linearly to the square root of the average number of acquisitions without background subtraction, which means that almost no systematic noise existed in our signal bandwidth of interest (a few hundreds megahertz). In comparison, 8-bit digitizers that are commonly used in the market require 32 times more pulses with background subtraction.