SEX DIFFERENCE IN RESTING PITUITARY-ADRENAL FUNCTION IN RAT
SEX DIFFERENCE IN RESTING PITUITARY-ADRENAL FUNCTION IN RAT
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DOI：
10.1152/ajplegacy.1963.205.5.807
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发表时间：
1963-01-01
影响因子：
--
通讯作者：
LIPSCOMB, HS
中科院分区：
文献类型：
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作者：
CRITCHLOW, V;BARSELA, M;LIPSCOMB, HS
在完整、去势、假去势成年和青春期前雄性和雌性大鼠中，在受控的24小时光暗周期期间，每隔一段时间测定血浆和肾上腺皮质类固醇的静息水平、垂体促肾上腺皮质激素含量和循环白细胞。为了研究环境照明节律的影响，皮质类固醇水平同样遵循在完整和盲雄性和雌性大鼠和卵巢切除雌性动物后，9小时的照明方案的转变。所有动物组均显示周期性垂体-肾上腺功能的证据，但成熟卵巢的存在与皮质类固醇水平昼夜波动的显著促进相关。此外，结果表明，负责垂体-肾上腺节律性的机制受到周期性卵巢功能的影响，对戊巴比妥敏感，并通过眼睛感知的环境照明节律同步。静息状态下垂体-肾上腺功能的几个特征类似于促性腺激素周期性释放导致排卵的特征。相似或重叠的神经机制可能是这些内分泌节律的原因。
Resting levels of plasma and adrenal corticosteroids, pituitary content of adrenocorticotropin, and circulating leukocytes were determined at intervals during controlled 24-hr light-dark cycles in intact, castrated, sham-castrated adult and prepubertal male and female rats. To study the influence of environmental lighting rhythms, corti-costeroid levels were similarly followed in intact and blinded male and female rats and in ovariectomized females following a 9-hr shift in lighting regimen. All groups of animals showed evidence of cyclic pituitary-adrenal function, but the presence of mature ovaries was associated with marked facilitation of the diurnal excursions in corticosteroid levels. Furthermore, the results indicated that the mechanisms responsible for pituitary-adrenal rhythmicity are influenced by cyclic ovarian function, are sensitive to pentobarbital, and are synchronized by environmental lighting rhythms perceived through the eyes. Several of the features of pituitary-adrenal function under resting conditions resemble those associated with cyclic release of gonadotropin leading to ovulation. Similar or overlapping neural mechanisms may be responsible for these endocrine rhythms.