Ovarian cancer pathogenesis: a model in evolution.
Ovarian cancer pathogenesis: a model in evolution.
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DOI：
10.1155/2010/932371
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发表时间：
2010
影响因子：
--
通讯作者：
Drapkin R
中科院分区：
文献类型：
--
作者：
Karst AM;Drapkin R
卵巢癌是一种致命的疾病，目前还没有有效的早期检测手段。卵巢癌由多种肿瘤组成，表现出广泛的形态特征、临床表现、遗传改变和肿瘤行为。这种高度的异质性给卵巢癌的诊断和治疗带来了重大的临床挑战。此外，导致卵巢癌发生的早期事件知之甚少，因此使开发这种疾病的筛查方法的努力复杂化。在这里，我们提供了卵巢癌发病机制的现有模型的概述，重点介绍了最近的发现，即输卵管伞状物可能是卵巢癌的起源部位。随着我们更多地了解卵巢癌的遗传学和病因学，卵巢癌模型将继续进化。
Ovarian cancer is a deadly disease for which there is no effective means of early detection. Ovarian carcinomas comprise a diverse group of neoplasms, exhibiting a wide range of morphological characteristics, clinical manifestations, genetic alterations, and tumor behaviors. This high degree of heterogeneity presents a major clinical challenge in both diagnosing and treating ovarian cancer. Furthermore, the early events leading to ovarian carcinoma development are poorly understood, thus complicating efforts to develop screening modalities for this disease. Here, we provide an overview of the current models of ovarian cancer pathogenesis, highlighting recent findings implicating the fallopian tube fimbria as a possible site of origin of ovarian carcinomas. The ovarian cancer model will continue to evolve as we learn more about the genetics and etiology of this disease.