Inhibition of HIV replication by naphthalenemonosulfonic acid derivatives and a bis naphthalenedisulfonic acid compound.
Inhibition of HIV replication by naphthalenemonosulfonic acid derivatives and a bis naphthalenedisulfonic acid compound.
复制标题
萘单磺酸衍生物和双萘二磺酸化合物抑制 HIV 复制。
DOI：
10.1016/0024-3205(90)90471-3
复制
发表时间：
1990
期刊：
影响因子：
6.1
通讯作者：
P. Sarin
中科院分区：
文献类型：
--
作者：
P. Mohan;R. Singh;J. Wepsiec;I. González;D. Sun;P. Sarin
Several naphthalenemonosulfonic acid analogs and a bis naphthalenedisulfonic acid have been evaluated for anti-HIV activity in assays using H9 and MOLT-3 cells. Among the naphthalenemonosulfonic acids,a 4-amino-5-hydroxy compound and a 4,5-diamino compound showed low anti-HIV activity (upto 50% inhibition) at non-toxic doses. The bis naphthalenedisulfonic acid compound demonstrated significant suppression of HIV-1 antigen expression as measured by monoclonal antibodies to p17 (95%), p24 (94%) and syncytia inhibition (82%) at a dose of 20 μg/ml that was non-toxic to the host cells. The bis naphthalenedisulfonic acid analog represents a new class of compounds which may be effective in the treatment of HIV infected patients. The structure activity relationship and a probable mode of action of these compounds is discussed.
登录
查看更多内容
影响因子：
56.9
作者：
FRANKEL, AD;BREDT, DS;PABO, CO
通讯作者：
PABO, CO
影响因子：
7.3
作者：
MANSURI, MM;STARRETT, JE;MARTIN, JC
通讯作者：
MARTIN, JC
抑制 HIV 感染和细胞病变的合成 CD4 肽衍生物。
DOI：
10.1126/science.2969619
发表时间：
1988
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Lifson,JD;Hwang,KM;Nara,PL;Fraser,B;Padgett,M;Dunlop,NM;Eiden,LE
通讯作者：
Eiden,LE
影响因子：
56.9
作者：
LARDER, BA;DARBY, G;RICHMAN, DD
通讯作者：
RICHMAN, DD