Feeding circuit development and early-life influences on future feeding behaviour.
Feeding circuit development and early-life influences on future feeding behaviour.
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DOI：
10.1038/nrn.2018.23
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发表时间：
2018-04-17
期刊：
影响因子：
--
通讯作者：
Zeltser LM
中科院分区：
文献类型：
--
作者：
Zeltser LM
A wide range of maternal exposures– undernutrition, obesity, diabetes, stress and infection – are associated with increased risk of metabolic disease in offspring. Developmental influences can cause persistent structural changes in hypothalamic circuits regulating food intake in the service of energy balance. The physiological relevance of these alterations has been called into question because maternal impacts on daily caloric intake do not persist to adulthood. Recent behavioral and epidemiological studies in humans provide evidence that the relative contribution of appetitive traits related to satiety, reward and emotional aspects of food intake regulation changes across the lifespan. This article outlines a neurodevelopmental framework to explore the possibility that cross-talk between developing circuits regulating different modalities of food intake shapes future behavioral responses to environmental challenges.
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