Maquiroside A, a new cytotoxic cardiac glycoside from Maquira calophylla.
Maquiroside A, a new cytotoxic cardiac glycoside from Maquira calophylla.
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Maquiroside A，一种来自 Maquira calophylla 的新型细胞毒性强心苷。
DOI：
10.1021/np50050a015
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发表时间：
1987
影响因子：
5.1
通讯作者：
Sneden,AT
中科院分区：
文献类型：
--
作者：
Rovinski,JM;Tewalt,GL;Sneden,AT
Maquiroside A [1] 是一种新的强心苷，从秘鲁植物 Maquira calophylla 中分离出来。利用光谱方法确定了结构，发现苷元是cannogenol。糖部分被鉴定为D-cymarose。 Maquiroside A [1] 表现出对 KB 细胞培养物的活性。根据我们对具有潜在化疗价值的植物源性天然产物的持续兴趣，我们研究了 Maquira calophylla (P. & E.) CC Berg（桑科）的提取物，寻找可能具有抗肿瘤活性的化合物。尽管桑科的许多成员都经过了植物化学检查，但在我们调查之前还没有发表过对马基拉物种的检查。 M. calophylla 的原始提取物在体内表现出抗小鼠 P-388 淋巴细胞白血病的活性以及对 KB 细胞培养系统的细胞毒性 (1)。在针对 KB 细胞培养物的生物测定指导下，对 M. calophylla 茎皮的乙醇提取物进行分级分离，结果从非细胞毒性组分中分离出三种香豆素（marmesin、水合氧化前胡素和普兰菲罗）(2)。然而，由于成分的极性和主要成分的分解倾向，茎皮细胞毒性成分的分离和表征变得困难。我们现在报告主要细胞毒性成分的分离和结构阐明。 calophylla，maquiroside A [1]，一种新的强心苷。
Maquiroside A [1], a new cardiac glycoside, was isolated from the Peruvian plant Maquira calophylla. The structure was established using spectroscopic methods, and the aglycone was found to be cannogenol. The sugar portion was identified as D-cymarose. Maquiroside A [1] demonstrated activity against the KB cell culture.In accord with our continuing interest in plant-derived natural products with potential chemotherapeutic value, we have investigated extracts of Maquira calophylla (P. & E.) CC Berg (Moraceae) for compounds that exhibit possible antineoplastic ac-tivity. Although many members of the Moraceae family have been examined phy tochemically, there were no published examinations of Maquira species prior to our investigations. Original extracts of M. calophylla exhibited activity in vivo against the P-388 lymphocytic leukemia in miceand cytotoxicity against the KB cell culture sys-tem (1). Fractionation of ethanolic extracts of the stem bark of M. calophylla, guided by bioassays against the KB cell culture, resulted in the isolation of three coumarins (marmesin, oxypeucedanin hydrate, and pranferol) from non-cytotoxic fractions (2). However, isolation and characterization of the cytotoxic constituents of the stem bark were made difficult by the polarity of the constituents and the propensity of the major components to decompose. We now report the isolation and structure elucidation of the major cytotoxic constituent of. calophylla, maquiroside A [1], a new cardiac glycoside.