Mouse skin application in chemical carcinogenesis.
Mouse skin application in chemical carcinogenesis.
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小鼠皮肤在化学致癌作用中的应用。
DOI：
10.1159/000407257
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Melchionne,S
中科院分区：
文献类型：
--
作者：
VanDuuren,BL;Melchionne,S
用小鼠皮肤法测定油脂、焦油和化学品的致癌性已有60多年的历史[16,20,27,28]。该测试系统的使用导致了许多芳香烃的分离、表征和合成，这些芳香烃是化学致癌物中重要的一类。该测试系统在许多实验室中用于本综述中讨论的化学致癌作用的某些方面[11,25,31]。继续使用该模型的原因在于它在化学致癌研究中的价值。此外，测试材料的易于管理，准确定量地观察肿瘤出现率、肿瘤多样性、荧光性和其他毒性效应是决定该测试系统的重要因素。在最常用的实验动物，即小鼠、大鼠、家兔和豚鼠中，小鼠最容易受到化学制剂诱发皮肤肿瘤的影响。诱导的肿瘤为良性乳头状瘤，可退化或发展为鳞状癌。后者常见于人类；黑素瘤对人类来说有时是致命的，但很少发生在老鼠身上。
Mouse skin application has been used for the determination of car-cinogenicity of oils, tars and chemicals for more than 60 years [16, 20, 27, 28]. The use of this test system led to the isolation, characterization and synthesis of many aromatic hydrocarbons which constitute an important group of chemical carcinogens [7]. This test system is used in many laboratories in the pursuit of certain aspects of chemical carcinogenesis dis-cussed in this review [11, 25, 31]. The reasons for the continued use of this model center around its value in chemical carcinogenesis studies. In addition, the ease of administration of test materials, accurate and quan-titative observations of rate of tumor appearance, tumor multiplicity, irri-tancy and other toxic effects are important factors in deciding on this test system.Of laboratory animals most commonly used, ie, mice, rats, rabbits and guinea pigs, mice are the most susceptible to skin tumor induction by chemical agents. The tumors induced are benign papillomas which may regress or progress to squamous carcinomas. The latter are commonly encountered in humans; melanomas, which are at times fatal in humans [1], rarely occur in mice.