Human growth hormone and interleukin-6 are upregulated in endometriosis and endometrioid adenocarcinoma
Human growth hormone and interleukin-6 are upregulated in endometriosis and endometrioid adenocarcinoma
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DOI：
10.1016/j.acthis.2006.01.004
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发表时间：
2006-01-01
影响因子：
2.5
通讯作者：
Murphy, C. R.
中科院分区：
文献类型：
--
作者：
Slater, Michael;Cooper, M.;Murphy, C. R.
在这项对银行组织的回顾性定量研究中，我们发现，与正常子宫上皮细胞相比，子宫内膜异位症患者的生长激素(GH)增加了3.4倍，子宫内膜腺癌患者的生长激素(GH)增加了3.8倍。同样，白介素6(IL-6)在子宫内膜异位症中增加2.4倍，在子宫内膜腺癌中增加4.4倍。这些蛋白质似乎参与了这两种情况的进展。GH在这方面特别有趣，因为已知它不仅促进细胞增殖，而且还减少细胞与细胞的黏附，从而允许单个细胞脱离其亲本结构。我们的研究结果表明，IL-6和GH可能在子宫内膜异位症和子宫内膜癌的发生发展过程中起重要作用。(C)2006年，爱思唯尔股份有限公司出版。
In this retrospective and quantitated study on banked tissue we found that, compared to normal uterine epithelial, cells, growth hormone (GH) is increased 3.4-fold in endometriosis and 3.8-fold in endometrial adenocarcinoma. Similarly, interleukin-6 (IL-6) is increased 2.4-fold in endometriosis and 4.4-fold in endometrial adenocarcinoma. These proteins appear to be involved in the progression of both these conditions. GH is particularly interesting in this context since it is known to not only promote cellular proliferation but also reduces cell-cell adhesion, thus allowing individual cells to break away from their parent architecture. Our results suggest that both IL-6 and GH may play a rote in the progression of both endometriosis and endometrial carcinoma. (C) 2006 Published by Elsevier GmbH.