Neurosteroids for the potential protection of humans against organophosphate toxicity.
Neurosteroids for the potential protection of humans against organophosphate toxicity.
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DOI：
10.1111/nyas.13160
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发表时间：
2016-08
影响因子：
5.2
通讯作者：
Reddy DS
中科院分区：
文献类型：
--
作者：
Reddy DS
This article describes the therapeutic potential of neurosteroids as anticonvulsant antidotes for chemical intoxication caused by organophosphate pesticides and nerve agents or gases like sarin and soman. Toxic manifestations following nerve agent exposure, as evident in chemical attacks in Japan and Syria, include hypersecretion, respiratory distress, tremors, convulsions leading to status epilepticus (SE), and death. Benzodiazepines, such as diazepam, are the current anticonvulsants of choice for controlling nerve agent–induced life-threatening seizures, SE, and brain injury. Benzodiazepines can control acute seizures when given early, but they are less effective for delayed treatment of SE, which is characterized by rapid desensitization of synaptic GABAA receptors, benzodiazepine resistance, and brain injury. Neurosteroid-sensitive, extrasynaptic GABAA receptors remain unaffected by such events, however. Thus, anticonvulsant neurosteroids may produce more effective protection than benzodiazepines against a broad spectrum of chemical agents, even when given late after nerve agent exposure.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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