A Follicle-Stimulating Hormone Exacerbates the Progression of Periapical Inflammation Through Modulating the Cytokine Release in Periodontal Tissue
A Follicle-Stimulating Hormone Exacerbates the Progression of Periapical Inflammation Through Modulating the Cytokine Release in Periodontal Tissue
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毛囊刺激激素通过调节牙周组织中细胞因子的释放而加剧根尖周炎症的进展。
DOI：
10.1007/s10753-020-01234-9
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发表时间：
2020-08-01
期刊：
影响因子：
5.1
通讯作者：
Ji, Yaoting
中科院分区：
文献类型：
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作者：
Qian, Hua;Jia, Jie;Ji, Yaoting
绝经期与全身性炎症程度低直接相关，表明绝经后妇女可能更容易发生炎症。高水平的循环卵泡刺激素（FSH）可能导致性腺功能低下的骨质流失在绝经后骨质疏松症独立雌激素。既往研究发现，FSH可加重去卵巢大鼠实验性根尖周围病变时的牙槽骨丢失；然而，这些影响的机制仍不清楚。在本研究中，我们发现FSH显著增强了人牙周韧带（hPDL）细胞中促炎细胞因子白细胞介素(IL)-1 β、IL-6和肿瘤坏死因子α的表达和分泌。此外，FSH上调牙龈卟啉单胞菌脂多糖（pgLPS）诱导的促炎细胞因子的产生。此外，体内研究表明，FSH增加了血清中上述细胞因子的水平，并增强了hPDL细胞和牙周组织中toll样受体4在信使RNA和蛋白质水平上的表达。我们的研究提示，高FSH水平可能调节绝经后牙周组织的免疫状态，并在一定程度上提示绝经后妇女可能更容易发生根尖周炎炎症，骨质流失更明显。
Abstract Menopause is directly related to a systemically low grade of inflammation, indicating that postmenopausal women might be more prone to the development of inflammation. The high levels of circulating follicle-stimulating hormone (FSH) may cause hypogonadal bone loss during postmenopausal osteoporosis independent of estrogen. Previous research revealed that FSH could aggravate alveolar bone loss during experimental periapical lesions in ovariectomized rats; however, the mechanisms for these effects remain unclear. In this study, we showed that FSH enhanced the expression and secretion of the proinflammatory cytokines interleukin (IL)-1 beta, IL-6, and tumor necrosis factor alpha to a significant degree in human periodontal ligament (hPDL) cells. Furthermore, FSH upregulatedPorphyromonas gingivalislipopolysaccharide (pgLPS)-induced proinflammatory cytokine production. Furthermore,in vivostudies demonstrated that FSH increased the levels of the aforementioned cytokines in the serum and enhanced the expression of Toll-like receptor 4 at both the messenger RNA and protein levels in hPDL cells and periodontal tissues. Our research suggests that high FSH levels may regulate the immune status of periodontal tissues during the postmenopausal period and, to a certain extent, suggested that postmenopausal women might be more prone to the development of inflammation of the periapical periodontitis and more obvious bone loss.