CATECHOLAMINE RELEASE IN NEWBORN-INFANT AT BIRTH
CATECHOLAMINE RELEASE IN NEWBORN-INFANT AT BIRTH
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DOI：
10.1203/00006450-197708000-00007
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发表时间：
1977-01-01
影响因子：
3.6
通讯作者：
BISTOLETTI, P
中科院分区：
文献类型：
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作者：
LAGERCRANTZ, H;BISTOLETTI, P
用荧光法测定新生儿出生后立即采集的脐血中的儿茶酚胺。正常分娩的足月新生儿脐动脉和脐静脉中的平均儿茶酚胺浓度分别为62.1 nmol/l和29.3 nmol/l。这一数值远高于静止的成年人。类似的水平，儿茶酚胺后，择期剖宫产，而相当高的水平后，臀位分娩。在足月窒息儿中，发现脐动、静脉血中的儿茶酚胺浓度增加约4倍。胺浓度水平与低于7.25的pH呈负相关（10 log儿茶酚胺浓度对pH，r = 0.71）。早产儿，在一般情况下，较低的胺水平比足月婴儿后顺利分娩和宫内窒息。在出生前最后一小时内表现出某种异常胎心率变化的新生儿中，儿茶酚胺水平显著增加;特别是基线变化与高水平相关，而在心跳间变化消失后仅出现中度增加。
Catecholamines were determined by a fluorimetric technique in umbilical blood which was collected from newborn infants immediately after birth. The mean catecholamine concentration was 62.1 nmol/l in the umbilical artery and 29.3 nmol/l in the umbilical vein of newborn full term infants delivered uneventfully. This value is considerably higher than in resting adults. Similar levels of catecholamines were seen after elective cesarean sections, whereas considerably higher levels were found after breech deliveries. In the full term asphyxiated infants about a 4-fold increase of the catecholamine concentration was found in both the umbilical arterial and venous blood. The amine concentration level correlated inversely to the pH below 7.25 (10log catecholamine concentration versus pH, r = 0.71). Preterm infants had, in general, lower amine levels than full term infants both after uneventful deliveries and after intrauterine asphyxia. The catecholamine levels were considerably increased in the newborn infants who showed some kind of abnormal fetal heart rate variation during the last hour before birth; in particular baseline changes were associated with high levels whereas only a moderate increase was seen after loss of beat-to-beat variation.