Mechanical properties of blood clots - a new test method
Mechanical properties of blood clots - a new test method
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DOI：
10.1002/mawe.201000703
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发表时间：
2010-12-01
影响因子：
1.1
通讯作者：
Monstadt, H.
中科院分区：
文献类型：
--
作者：
Krasokha, N.;Theisen, W.;Monstadt, H.
血凝块需要具有适当程度的机械、化学和生物学特性以阻止血液流动，并且还适合于溶解酶或机械血栓切除术，以便不形成血栓形成事件。这些机械性能的起源和理解仍然不清楚。血凝块由纤维蛋白纤维的三维网络组成，通过与转氨酶（因子XIIIa）连接而稳定。在这项工作中建立了新的方法来获得有关机械性能的信息。我们进行了老年人血凝块的抗压强度实验。此外，在建立新的测试环境后，可以对老化的动物血凝块进行拉伸强度测量。测定了老化血栓的应力-应变曲线并进行了讨论。定量描述了凝块材料的粘弹性。这项工作应作出贡献，更好地了解老年血栓散装材料的行为和诱导的机械应力。
A blood clot needs to have the right degree of mechanical, chemical and biological properties to stem the flow of blood and yet to be suitable for lytic enzymes or mechanical thrombectomy so as not to form a thrombotic event. The origin and understanding of these mechanical properties are still not known in detail. Clots are made of a three-dimensional network of fibrin fibers stabilized through ligation with a transglutaminase, factor XIIIa. New methods to achieve information about mechanical properties were established in this work. We performed compressive strength experiments of aged human blood clots. Furthermore after the set up of a new test environment, it was possible to perform tensile strength measurements of aged animal blood clots. Stress strain curves of aged clots were measured and discussed. The viscoelastic properties of the clot material were quantitatively described. This work should make a contribution to a better understanding of the behaviour of aged blood thrombus bulk material and induced mechanical stress.