Synthesis and Biological Evaluation of Bromo- and Fluorodanicalipin A
Synthesis and Biological Evaluation of Bromo- and Fluorodanicalipin A
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DOI：
10.1002/anie.201510608
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发表时间：
2016-02-12
影响因子：
16.6
通讯作者：
Carreira, Erick M.
中科院分区：
文献类型：
--
作者：
Fischer, Stefan;Huwyler, Nikolas;Carreira, Erick M.
我们披露了（+） - 溴二氨基汀A以及（O）-FluorodanicalipinA的合成。通过基于J Danicitipin A.此外，初步毒理学研究表明，Danicilipina的不利影响可能是由于亲脂性而引起的卤素。
We disclose the syntheses of (+)-bromodanicalipin A as well as (o)-fluorodanicalipin A. The relative configuration and ground-state conformation in solution of both molecules was secured by J-based configuration analysis which revealed that these are identical to natural danicalipin A. Furthermore, preliminary toxicological investigations suggest that the adverse effect of danicalipinA may be due to the lipophilicity of the halogens.