ROLE OF CORTICOTROPIN-RELEASING FACTOR (CRF) AS A FOOD-INTAKE REGULATOR IN GOLDFISH
ROLE OF CORTICOTROPIN-RELEASING FACTOR (CRF) AS A FOOD-INTAKE REGULATOR IN GOLDFISH
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DOI：
10.1016/0031-9384(93)90146-7
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发表时间：
1993-03-01
影响因子：
2.9
通讯作者：
ALONSOBEDATE, M
中科院分区：
文献类型：
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作者：
DEPEDRO, N;ALONSOGOMEZ, AL;ALONSOBEDATE, M
研究了在剥夺食物24小时后，金鱼腹腔或脑室内注射促肾上腺皮质激素释放因子（CRF）对摄食量的影响。在注射后0-2、2-8和0-8小时的不同时间段评估食物摄入量。1杯和2杯剂量的CRF脑室内注射诱导前2小时食物摄入量减少，尽管在接下来的6小时内观察到摄食增加。本研究中使用的较高剂量的CRF（3.3杯）增加了注射后8小时的累积食物摄入量。然而，在任何研究间隔内，腹腔注射1杯CRF并没有改变食物摄入量。这些结果表明，CRF可能在金鱼摄食行为的中枢调节中发挥作用，并表明CRF的作用具有时间和剂量依赖性。
The effect of intraperitoneal or intracerebroventricular corticotropin-releasing factor (CRF) administration on food intake has been studied in goldfish after 24 h of food deprivation. Food intake was evaluated at different time periods after injection, 0-2, 2-8, and 0-8 h. The 1 and 2 mug doses of CRF intracerebroventricutarly administered induced a reduction in food intake during the first 2 h, although an increased feeding was observed in the next 6 h. The higher dose of CRF used in this study (3.3 mug) increased cumulative food intake at 8 h postinjection. However, intraperitoneal injection of 1 mug CRF did not modify food intake in any of the studied intervals. These results suggest thal CRF may play a role in central regulation of feeding behavior intake in goldfish, and show that CRF effects are time- and dose-dependent.