Influence of the OPRM1 gene polymorphism upon children's degree of withdrawal and brain activation in response to facial expressions
Influence of the OPRM1 gene polymorphism upon children's degree of withdrawal and brain activation in response to facial expressions
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DOI：
10.1016/j.dcn.2011.05.001
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发表时间：
2012-01-01
影响因子：
4.7
通讯作者：
Battaglia, Marco
中科院分区：
文献类型：
--
作者：
Bertoletti, Eleonora;Zanoni, Annalisa;Battaglia, Marco
μ阿片受体基因（OPRM 1）的A118 G多态性的遗传变异预测了成人模拟社会排斥过程中个体对社会排斥和fMRI激活的敏感性，而缺乏儿童时期这些关系的数据。我们研究了这种多态性是否可以预测儿童期退缩-对社会排斥敏感性的预测因子-以及面部表情的面部特异性N170事件相关波形。在面部表情中，“愤怒”被认为是特别令人回味的，因为它传达了社会排斥。49名8-10岁的儿童被描述为他们的OPRM 1基因型，他们在儿童行为检查表（CBCL）的退缩量表中的得分，以及在内隐处理其他儿童的快乐，中性和愤怒表情的任务中记录的N170潜伏期和振幅。携带OPRM 1-G等位基因的儿童在对面部表情的反应中具有较高的CBCL退缩评分和增强的N170振幅。多元线性回归分析表明，退缩量表得分预测较大的N170振幅在Pz和C4电极，只有愤怒expression.Children携带一个或两个拷贝的OPRM 1 G-等位基因更容易表现出退缩行为，和不同的电生理反应的早期阶段的处理情感刺激。(C)2011爱思唯尔有限公司保留所有权利。
Genetic variation of the A118G polymorphism of the mu-opioid receptor gene (OPRM1) predicts individual sensitivity to social rejection and fMRI activation during simulated social rejection in adults, while data on these relationships during childhood are lacking. We investigated whether this polymorphism predicts childhood withdrawal - a predictor of sensitivity to social rejection -, and the face-specific N170 event-related waveform in response to facial expressions. Among facial expressions, 'anger' was expected to be particularly evocative, as it communicates social rejection.Forty-nine children aged 8-10 years were characterised for their OPRM1 genotype, their score at the Withdrawn Scale of the Child Behavior Checklist (CBCL), and for N170 latencies and amplitudes recorded during a task of implicit processing of happy, neutral, and angry expressions of other children. Children carrying the OPRM1-G allele had higher CBCL Withdrawn scores and enhanced N170 amplitudes in response to facial expressions. Multiple linear regressions showed that the Withdrawn scale score predicts larger N170 amplitudes at the Pz and C4 electrodes, only for the anger expression.Children who carry one or two copies of the OPRM1 G-allele are more likely to manifest withdrawn behaviours, and differ for electrophysiological responses to the early phases of processing affective stimuli. (C) 2011 Elsevier Ltd. All rights reserved.