Attoliter Chemistry for Nanoscale Functionalization of Graphene.
Attoliter Chemistry for Nanoscale Functionalization of Graphene.
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DOI：
10.1021/acsami.6b06065
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发表时间：
2016-12
影响因子：
9.5
通讯作者：
Michael Hirtz;Sarah A Varey;H. Fuchs;A. Vijayaraghavan
中科院分区：
文献类型：
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作者：
Michael Hirtz;Sarah A Varey;H. Fuchs;A. Vijayaraghavan
石墨烯在器件阵列中的纳米级多功能化是实现石墨烯基化学和生物传感器的关键步骤。我们证明，石墨烯可以功能化亚微米分辨率和明确定义的位置和图案，使用反应剂的阿升量，利用蘸笔纳米光刻或微通道悬臂斑点。具体来说，我们使用点击化学用生物素叠氮化物官能化石墨烯，并证明随后的荧光标记的链霉亲和素的结合。该技术可以按比例放大，以在晶圆级上对石墨烯器件进行多功能化，用于传感器和生物医学应用。
The nanoscale, multiplexed functionalization of graphene in a device array is a critical step to realize graphene-based chemical and biosensors. We demonstrate that graphene can be functionalized with submicron resolution and in well-defined locations and patterns using reaction agents in attoliter quantities, utilizing dip-pen nanolithography or microchannel cantilever spotting. Specifically, we functionalize graphene with a biotin azide using click-chemistry and demonstrate the subsequent binding of fluorescently tagged streptavidin. The technique can be scaled up to multiplex functionalize graphene devices on a wafer-scale for sensor and biomedical applications.