Molecular mechanisms and treatment of bone metastasis
Molecular mechanisms and treatment of bone metastasis
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DOI：
10.1017/s1462399408000616
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发表时间：
2008-03-06
影响因子：
6.2
通讯作者：
Guise, Theresa A.
中科院分区：
文献类型：
--
作者：
Clines, Gregory A.;Guise, Theresa A.
癌细胞向骨的转移改变了骨结构和矿物质稳态。正如“种子和土壤”假说所描述的，骨骼是癌细胞繁殖的沃土。骨癌细胞信号交互的“恶性循环”与溶骨（骨吸收）转移一起发生，并且类似的机制也可能调节成骨（骨形成）转移病变。阻断初始癌细胞趋化、侵袭和粘附或打破“恶性循环”的靶向疗法的开发取决于对骨转移的更全面的了解。尽管双磷酸盐可以延缓骨骼转移的进展，但显然需要更有效的治疗方法。癌症相关的骨发病率仍然是一个主要的公共卫生问题，为了改善治疗和预防，了解癌症对骨影响的病理生理学非常重要。这篇综述详细介绍了该领域的科学进展。
The metastasis of cancer cells to bone alters bone architecture and mineral homeostasis. As described by the 'seed and soil' hypothesis, bone represents a fertile ground for cancer cells to flourish. A 'vicious cycle' of reciprocal bone-cancer cellular signals occurs with osteolytic (bone-resorbing) metastases, and a similar mechanism likely modulates osteoblastic (bone-forming) metastatic lesions as well. The development of targeted therapies either to block initial cancer cell chemotaxis, invasion and adhesion or to break the 'vicious cycle' is dependent on a more complete understanding of bone metastases. Although bisphosphonates delay progression of skeletal metastases, it is clear that more-effective therapies are needed. Cancer-associated bone morbidity remains a major public health problem, and to improve therapy and prevention it is important to understand the pathophysiology of the effects of cancer on bone. This review details scientific advances in this area.