Trans-synaptic retrograde degeneration in the visual system of primates
Trans-synaptic retrograde degeneration in the visual system of primates
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灵长类动物视觉系统的跨突触逆行变性
DOI：
10.1136/jnnp.26.5.402
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发表时间：
1963
期刊：
影响因子：
--
通讯作者：
J. M. Buren
中科院分区：
文献类型：
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作者：
J. M. Buren
尽管神经系统中跨突触变性的首次观察是在世纪，但这种现象并不常见。从实验的角度来看，它不是一个特别有吸引力的研究领域，因为充分的效果变得明显需要时间，可能需要数月甚至数年的等待。因此，大多数观察都是在人体中进行的。自然发生的人体病变，甚至是陈旧性脑梗死，这可能是最有用的解剖目的，实际上从来没有接近实验消融的离散性，因为脑血管疾病很少是一个局部的过程。虽然这些材料很有价值，但神经病理学家通常不能对整个大脑进行连续切片的全面研究，因此人们会有一种不太舒服的想法，即在神经病理学取样中可能遗漏了重要的病变。在另一项关于灵长类视网膜神经节细胞层的局部解剖学研究（范布伦，1963）中，在视觉系统中放置了长期慢性损伤。这项研究提出了三个逆行性跨突触变性的情况下。2例在视交叉切断神经节细胞轴突后，视网膜内核层出现空洞变性。在最后一个病例中，枕叶消融后视网膜神经节细胞层变性。
Although the first observations of trans-synaptic degeneration in the nervous system were made in the nineteenth century, the phenomenon has been something of an infrequent curiosity. From an experimental point of view it is not a particularly attractive field for study due to the time required for the full effects to become evident and may entail many months or even years of waiting. Consequently the majority of the observations have been made in man. Naturally occurring human lesions, even old cerebral infarctions, which are perhaps the most useful for anatomical purposes, practically never approach the discreteness of an experimental ablation since cerebral vascular disease is seldom a localized process. Although this material is of great value, usually the neuropathologist cannot undertake a comprehensive study of the entire brain in serial section so that one is left with the somewhat uncomfortable thought that possibly significant lesions had been missed in the neuropathological sampling. In the course of another study on the topographical anatomy of the ganglion cell layer of the retina in primates (Van Buren, 1963), long-term chronic lesions were placed in the visual system. This study presents three cases of retrograde trans-synaptic degeneration. In two cases cavitary degeneration appeared in the inner nuclear layer of the retina after section of the axons of the ganglion cells at the optic chiasm. In the last case degeneration of the ganglion cell layer of the retina followed an occipital ablation.