Occurrence of the microcystins MC-LW and MC-LF in Dutch surface waters and their contribution to total microcystin toxicity.
Occurrence of the microcystins MC-LW and MC-LF in Dutch surface waters and their contribution to total microcystin toxicity.
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DOI：
10.3390/md11072643
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发表时间：
2013-07-22
期刊：
影响因子：
5.4
通讯作者：
Lürling M
中科院分区：
文献类型：
--
作者：
Faassen EJ;Lürling M
微囊藻毒素(MC)是淡水系统中最常见的蓝藻毒素。许多MC变异体已经被鉴定出来，并且变异体的毒性不同。最近的研究表明，变种MC-LW和MC-LF的毒性可能比MC-LR更大，MC-LR是含量最高、最常用于风险评估的变种。由于荷兰对这两个变种的存在知之甚少，我们通过对88个水样和10个浮渣样品中8个MC变种((dm-7-)MC-RR、MC-YR、(dm-7-)MC-LR、MC-LY、MC-LW和MC-LF)的分析，确定了它们的存在。所有分析的MC变异体都被检测到，在32%的MC水样中存在MC-LW和/或MC-LF。当MC-LW和MC-LF存在时，它们对MC总浓度的贡献接近10%，但由于它们被怀疑具有较高的毒性，估计它们对MC总毒性的平均贡献至少为45%。鉴于MC-LW和MC-LF的频繁出现和可能的高毒性，基于不同MC变种的毒性贡献进行健康风险评估似乎比仅基于MC-LR浓度更好。
Microcystins (MCs) are the most frequently found cyanobacterial toxins in freshwater systems. Many MC variants have been identified and variants differ in their toxicity. Recent studies showed that the variants MC-LW and MC-LF might be more toxic than MC-LR, the variant that is most abundant and mostly used for risk assessments. As little is known about the presence of these two variants in The Netherlands, we determined their occurrence by analyzing 88 water samples and 10 scum samples for eight MC variants ((dm-7-)MC-RR, MC-YR, (dm-7-)MC-LR, MC-LY, MC-LW and MC-LF) by liquid chromatography with tandem mass spectrometry detection. All analyzed MC variants were detected, and MC-LW and/or MC-LF were present in 32% of the MC containing water samples. When MC-LW and MC-LF were present, they contributed to nearly 10% of the total MC concentrations, but due to their suspected high toxicity, their average contribution to the total MC toxicity was estimated to be at least 45%. Given the frequent occurrence and possible high toxicity of MC-LW and MC-LF, it seems better to base health risk assessments on the toxicity contributions of different MC variants than on MC-LR concentrations alone.
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影响因子：
10.4
作者：
Feurstein D;Kleinteich J;Heussner AH;Stemmer K;Dietrich DR
通讯作者：
Dietrich DR
DOI：
10.1002/aheh.200600641
发表时间：
2006-10-01
期刊：
ACTA HYDROCHIMICA ET HYDROBIOLOGICA
影响因子：
--
作者：
Pavlova, Vera;Babica, Pavel;Marsalek, Blahoslav
通讯作者：
Marsalek, Blahoslav
影响因子：
4.2
作者：
Vesterkvist PS;Misiorek JO;Spoof LE;Toivola DM;Meriluoto JA
通讯作者：
Meriluoto JA
影响因子：
5.7
作者：
Monks, Noel R.;Liu, Shuqian;Moscow, Jeffrey A.
通讯作者：
Moscow, Jeffrey A.
影响因子：
2.8
作者：
Vesterkvist, PSM;Meriluoto, JAO
通讯作者：
Meriluoto, JAO