Visual and circadian responses to light in aged retinally degenerate mice.
Visual and circadian responses to light in aged retinally degenerate mice.
复制标题
老年视网膜退化小鼠对光的视觉和昼夜节律反应。
DOI：
10.1016/0042-6989(94)90304-2
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发表时间：
1994
期刊：
影响因子：
1.8
通讯作者：
Foster,RG
中科院分区：
文献类型：
--
作者：
Provencio,I;Wong,S;Lederman,AB;Argamaso,SM;Foster,RG
视网膜退化（rd）小鼠的光感受器退化进程在出生后发育早期开始，导致60-70日龄时视杆细胞完全丧失，随后视锥细胞丧失更长时间。我们先前已经证明，80日龄的rdmice能够对短暂的光脉冲做出反应，改变其昼夜运动节律，这些动物表现出与野生型（+ / +）对照相同的敏感性。如果存活的视锥细胞介导了这些昼夜节律反应，那么我们可以预期，随着年龄的增长，小鼠昼夜节律系统的敏感性会下降，并与视锥细胞的丢失平行。我们证明，老龄小鼠（80-767天的年龄）仍然能够以与+ / +小鼠难以区分的方式光调节昼夜运动节律。对光线的昼夜节律反应与小鼠视锥细胞变性不平行。与对光的昼夜节律反应相反，老年（> 210日龄）小鼠没有视觉诱发的行为或视网膜电图（ERG）反应。
The progression of photoreceptor degeneration in retinally degenerate (rd) mice commences early in postnatal development resulting in the complete loss of rods by 60–70 days of age followed by the more protracted loss of cones. We have previously shown thatrdmice 80 days of age are capable of phase shifting their circadian locomotor rhythms in response to brief pulses of light and these animals show the same sensitivity as wild-type ( + / + ) controls. If surviving cones mediate these circadian responses, then one would expect the sensitivity of the circadian system inrdmice to decline with age and parallel the loss of cones. We demonstrate that agingrdmice (80–767 days of age) remain capable of photically regulating circadian locomotor rhythms in a manner indistinguishable from + / + mice. Circadian responses to light do not parallel cone cell degeneration inrdmice. In contrast to the circadian responses to light, old (> 210 days of age)rdmice show no visually-evoked behavioral or electroretinogram (ERG) responses.