Biomimetic hydroxylation of nonactivated CH2 groups with copper complexes and molecular oxygen
Biomimetic hydroxylation of nonactivated CH2 groups with copper complexes and molecular oxygen
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DOI：
10.1002/anie.200250815
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发表时间：
2003-01-01
影响因子：
16.6
通讯作者：
Görls, H
中科院分区：
文献类型：
--
作者：
Schönecker, B;Zheldakova, T;Görls, H
铜（I）与甾体配体（见式）的配合物在分子氧存在下在甾体的12 β-位发生区域和立体选择性γ-羟基化。还原后得到17 β，12 β-氨基醇。在水解条件下，可分离出12 β-羟基-17-酮。
Copper (I) complexes with steroidal ligands (see formula) undergo regio-and stereoselective γ-hydroxylation in the 12β-position of the steroid in the presence of molecular oxygen. After reduction a 17β, 12β-amino alcohol is obtained. Under hydrolytic conditions a 12β-hydroxy-17-ketone can be isolated.